Prevalence of Multiple Drug Resistant Clinical Isolates of Extended-Spectrum Beta-Lactamase Producing Enterobacteriaceae in Southeast Iran

نویسندگان

  • Samaneh Abbasi
چکیده مقاله:

Background: Multidrug resistance and production of extended spectrum β-lactamases (ESBLs) by enteric gram-negative rods in hospitals and community continue to be worsened. We aimed to characterize the multidrug resistance and determine the prevalence of ESBL production by clinical isolates of Enterobacteriaceae in southeast Iran. Methods: Gram-negative bacteria isolated from clinical samples of hospital inpatients and outpatients from three hospitals in southeast Iran were tested for susceptibility to 10 commonly used antimicrobials. For 500 isolates which showed resistance to ≥3 antibiotics from different classes, minimum inhibitory concentration, and prevalence of ESBL production were determined by agar dilution and double disc synergy method respectively. The isolated bacterial species were compared in respect of antibacterial resistance, ESBL production, patients' gender, hospital ward, and type of specimen. Results: The most frequent resistance was to trimethoprim/ sulfamethoxazole, amoxicillin, and tetracycline. Imipenem with 99.8% and ceftizoxime with 83% susceptibility were the most active agents. A total of 53.8% of isolates expressed ESBL production. Escherichia coli and Klebsiella pneumoniae were most common in outpatients, and inpatients samples respectively. Higher rate of resistance to most antibacterial agents and ESBL production was found in samples of inpatients. Conclusion: The present study showed high prevalence of ESBL-producing Enterobacteriaceae especially in the patients admitted to hospital. Infection control strategy with continuous resistance surveillance is essential to monitor in vitro susceptibility to antibacterial agents currently used in clinical practice. Determination of the type of involved ESBL enzymes is important for a better antimicrobial control and empirical therapy of critically ill patients in hospitals.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

prevalence of multiple drug resistant clinical isolates of extended-spectrum beta-lactamase producing enterobacteriaceae in southeast iran

background: multidrug resistance and production of extended spectrum β-lactamases (esbls) by enteric gram-negative rods in hospitals and community continue to be worsened. we aimed to characterize the multidrug resistance and determine the prevalence of esbl production by clinical isolates of enterobacteriaceae in southeast iran.   methods: gram-negative bacteria isolated from clinical samples ...

متن کامل

Prevalence of extended-spectrum beta-lactamase-producing Enterobacteriaceae in Bahrain.

OBJECTIVES To determine the occurrence of extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae in Bahrain. METHODS Retrospective analysis of records (January 2005-December 2006) at the Microbiology Laboratory of the Salmaniya Medical Complex, Bahrain which is the major national diagnostic laboratory. RESULTS Out of a total of 11,886 member of family of Enterobacteriaceae iso...

متن کامل

High Prevalence of CTXM-15 Type Extended-Spectrum Beta-Lactamase Among Clinical Isolates of Klebsiella Pneumoniae

Background: Production of β–lactamases by enterobacteriacea, especially Klebsiella pneumoniae, is one of the emerging health problems in the world. The purpose of this study was to assess the frequency of blaCTX-M15 gene in K. pneumoniae isolates and determine the molecular diversity of CTXM producing isolates. Methods: In...

متن کامل

High prevalence of extended-spectrum ß-lactamase producing enterobacteriaceae among clinical isolates in Burkina Faso

BACKGROUND Nothing is known about the epidemiology and resistance mechanisms of extended-spectrum ß-lactamase-producing Enterobacteriaceae (ESBL-PE) in Burkina Faso. The objective of this study was to determine ESBL-PE prevalence and to characterize ESBL genes in Burkina Faso. METHODS During 2 months (June-July 2014), 1602 clinical samples were sent for bacteriologic investigations to the mic...

متن کامل

Activity of beta-lactam beta-lactamase inhibitor combinations against extended spectrum Beta-lactamase producing Enterobacteriaceae in urinary isolates.

OBJECTIVE To determine the susceptibility pattern of beta-lactam beta-lactamase inhibitor combinations against extended-spectrum beta-lactamase (ESBL) producing Enterobacteriaceae in urinary isolates. STUDY DESIGN Observational study. PLACE AND DURATION OF STUDY Ziauddin University Hospital, Karachi, from February to October 2008. METHODOLOGY A total of 190 consecutive non-duplicate isola...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


عنوان ژورنال

دوره 35  شماره 2

صفحات  101- 108

تاریخ انتشار 2010-06-01

با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.

کلمات کلیدی

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023