Protective effect of interleukin-36 receptor antagonist on liver injury induced by concanavalin A in mice


  • Jun Tan Department of Hepatology, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo 315010, China
  • Mingcai Li Department of Immunology, Medical School of Ningbo University, Ningbo 315211, China
  • Xiao Peng Department of Immunology, Medical School of Ningbo University, Ningbo 315211, China
  • Xiuhe Pan Department of Immunology, Medical School of Ningbo University, Ningbo 315211, China
  • Yan Li Department of Immunology, Medical School of Ningbo University, Ningbo 315211, China
چکیده مقاله:

Objective(s): Interleukin-36 receptor antagonist (IL-36Ra) is a new member of the IL-1 family that exhibits anti-inflammatory activity in a variety of inflammatory and immune diseases. Our purpose was to determine the effect of IL-36Ra on liver injury in a mouse hepatitis model induced by concanavalin A (ConA). Materials and Methods: Mice were treated with IL-36Ra DNA or pcDNA3.1 control plasmid using a hydrodynamic gene delivery approach. Results: Our data reveal that treatment with IL-36Ra decreased liver inflammation and serum level of aminotransferases. Furthermore, IL-36Ra reduced ConA-induced pro-inflammatory cytokines (interferon-γ, tumor necrosis factor-α, and IL-17A) production when compared to control plasmid. Conclusion: Our results demonstrated that IL-36Ra is a critical protector against ConA-induced liver injury.

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عنوان ژورنال

دوره 23  شماره 5

صفحات  623- 628

تاریخ انتشار 2020-05-01

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