Protective effects of omega-3, atorvastatin, vitamin E and vitamin C against doxorubicin-induced cardiotoxicity in rats: a comparison study


  • Abbas Alimoradian Molecular and Medicine Research Center, Department of Pharmacology, School of Medicine, Arak University of Medical
  • Ali Chehrei Endocrinology and Metabolism Research Center, Arak University of Medical Sciences, Arak, Iran
  • Hadi Ansarihadipour Molecular and Medicine Research Center, Department of Biochemistry and Genetics, School of Medicine, Arak University
  • Reza Talebi Department of Anatomy, Arak University of Medical Sciences, Arak, Iran
  • Sadaf Davudian mmunopharmacology Lab, Humanitas Research Hospital, 20089 Rozzano, Milan, Italy
  • Soheila Rostami Student Research Committee, Arak University of Medical Sciences, Arak, Iran
چکیده مقاله:

Introduction: The stress-oxidative is involved in doxorubicin (DOX)-induced cardiotoxicity. Due to the potential and previous reported for antioxidant properties of atorvastatin, omega-3, vitamin E and vitamin C, their efficacy to prevention of DOX-induced cardiotoxicity was investigated in this study. Methods: Fifty-six male rats were divided into 8 groups which received omega-3, atorvastatin, vitamin E, vitamin C, normal saline and dimethyl sulfoxide (DMSO) via gavage for 14 days then a single dose of DOX (20 mg/kg) was injected intraperitoneally except two last groups that received only normal saline or DMSO. The level of oxidative stress parameters like ferric reducing ability of plasma (FRAP) before and after DOX injection and malondialdehyde (MDA) of heart were estimated. Also the histopathologic assessments were done on heart sample at the end of experimental period. Results: The results showed that compared to other agents, omega-3 could emerge as the most protection against DOX. Its pretreatment led to one of the most FRAP changing percent meanwhile less MDA value and cardio pathologic indexes almost close to control groups compared to that of other agents (P<0.01). Conclusion: Omega-3 may have a promising protective effect against DOX-induced cardio toxicity.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Protective effects of famotidine and vitamin C against radiation induced cellular damage in mouse spermatogenesis process

Background: Radioprotective effect of famotidine was previously shown on radiation induced micronuclei and chromosomal aberrations in human peripheral lymphocytes and mouse bone marrow cells however, its radioprotective property has never been studied in mouse spermatogenesis. It was also shown that vitamin C as an antioxidant also exert its radioprotective effect on many biological s...

متن کامل

Vitamin E protection against gentamicin-induced nephrotoxicity in rats: a biochemical and histopathologic study

The specificity of gentamicin for vitamin E deficiency-associated oxidative stresses in the renal proximal convoluted tubules is apparently related to its ability to increasingly facilitate generation of radical species in mitochondria. To determine the ways in which vitamin E manage the currently processes, we conducted a prospective study aimed to investigate the tubular preserving effect of ...

متن کامل

In Vivo Protective Effects of Diosgenin against Doxorubicin-Induced Cardiotoxicity

Doxorubicin (DOX) induces oxidative stress leading to cardiotoxicity. Diosgenin, a steroidal saponin of Dioscorea opposita, has been reported to have antioxidant activity. Our study was aimed to find out the protective effect of diosgenin against DOX-induced cardiotoxicity in mice. DOX treatment led to a significant decrease in the ratio of heart weight to body weight, and increases in the bloo...

متن کامل

Protective Effects of Lycopene and Tomato Extract Against Doxorubicin-Induced Cardiotoxicity

       The protective effect of tomato extract and lycopene on acute doxorubicin-induced myocardial toxicity was evaluated in mice. Doxorubicin toxicity, induced by a single intraperitoneal injection (15 mg/kg), was revealed by elevated serum CPKMB and histopathological observations. Tomato extract (1.2 and 2.4 g/kg, i.p.) and lycopene (1.7 and 3.5 mg/kg, i.p.), prevented the rise in serum CPKM...

متن کامل

The protective effects of vitamin E and C against oxidative stress induced by sulfasalazine in the testis of male adult rats

Background & Objective: Sulfasalazine (SASP) is a drug used for the treatment of inflammatory bowel diseases. SASP causes testicular damage. The aim of this study was to verify whether or not an additional supply of vitamin E or C or together prevent the toxic effect of SASP on the rat spermatogenesis. Materials & methods: Adult male wistar rats (150-200 gr) were divided into five groups (n=8)...

متن کامل

protective effect of vitamin c, vitamin b12 and omega-3 on lead-induced memory impairment in rat

lead belongs to the heavy metal group and is considered as an environmental contaminant. acute or chronic contact to lead can change the physiological function of human organs. one of the most important disorders following the lead exposure is neurotoxicity. lead neurotoxicity consists of the neurobehavioral disturbances like cognitive impairment. the aim of the current study is to evaluate the...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}

عنوان ژورنال

دوره 22  شماره None

صفحات  63- 72

تاریخ انتشار 2018-03

با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.

کلمات کلیدی

میزبانی شده توسط پلتفرم ابری

copyright © 2015-2023