Safety evaluation of oral Anethum graveolens L total hydroalcoholic extract in mice
نویسندگان: ثبت نشده
Anethum graveolens L. (dill) is used widely in Asian food and folk medicine but its safety profile for further clinical studies has remained unclear. After administration of total hydroalcoholic extract to mice in acute, subacute and subchronic treatment periods, toxic responses were recoreded by clinical, biochemical, hematological and pathological examinations. Doses up to 2000 mg/kg in acute study did not cause any mortality and doses up to 1000 mg/kg didn’t cause any toxic effect in subacute study. Following to daily administration of doses of 1000 mg/kg/day as Maximum Tolerated Dose (MTD) and doses of 50 (1/20 MTD), 500 (1/2MTD) and 1000 mg/kg (MTD) in 45 days regimen, signif cant falls in white cell counts was reported after 3 weeks (P-value < 0.05) in high (P-value = 0.042) and intermediate dose (P-value = 0.018) groups of male animals. Dill extract caused significant reduction of FBS in high dose female animal group (P-value = 0.021). Portal mononuclear lymphoid and PMN leucocytes infiltration in three adjacent foci were seen in intermediate and high dose groups of both sexes which was clearly a dose dependent effect. Doses less than 50 mg/kg could be consi ered as safe dose in both genders of mice with the good potential for further antihypoglycemic or antihyperlipidemic clinical studies
anethum graveolens l. (dill) is used widely in asian food and folk medicine but its safety profile for further clinical studies has remained unclear. after administration of total hydroalcoholic extract to mice in acute, subacute and subchronic treatment periods, toxic responses were recoreded by clinical, biochemical, hematological and pathological examinations. doses up to 2000 mg/kg in acute...متن کامل
Article Type Research Article Authors Roohbakhsh A.* PhD, Esmaeili H.1 BSc, Asami Z.1 BSc, Arab Baniasad F.1 MSc, Shamsizadeh A.1 PhD, Rezvani M. E.2 PhDمتن کامل
Lipid Lowering Effects of Hydroalcoholic Extract of Anethum graveolens L. and Dill Tablet in High Cholesterol Fed Hamsters.
Objective. This study was aimed to determine the effect of Anethum graveolens extract and Anethum graveolens (dill) tablet on lipid profile, liver enzymes, and gene expression and enzymatic activity of HMG-CoA reductase in high cholesterol fed hamsters. Materials and Methods. Golden Syrian male hamsters (130 ± 10 g) were randomly divided into 6 groups (n = 6) and received daily the following: g...متن کامل
BACKGROUND Giardia lamblia is the most common intestinal parasite of humans identified worldwide. In spite of metronidazole (Met) is the most commonly used drug for the treatment of giardiasis in humans, low patient compliance and side-effects, especially in children encourage efforts to look for new and safe agent; many plants used in folk medicine thought to have antigiardial effect, Anethum ...متن کامل
Evaluation of anti-nociceptive and anti-inflammatory activities of hydroalcoholic extract derived from root of Apium graveolens L. in mice
Background and objectives: Apium graveolens L. (celery) has been considered as sedative, analgesic, carminative, antispasmodic and diuretic plant in traditional Iranian medicine. The aim of the present study was to evaluate the anti-nociceptive and anti-inflammatory effect of celery root in mice. Methods: Analgesic effect of celery root was de...متن کامل
Anethum graveolens L. is a member of the Apiaceae family and more commonly known as dill. Dill has been used for gastrointestinal ailments such as flatulence, indigestion, stomach ache and colic. It has therapeutic effects such as mucosal protective, antisecretory, antimicrobial, antispasmodic, antihypercholesterolaemic and antihyperlipidaemic. The aim of our study was to examine the effects of...متن کامل
دوره 1 شماره 2
صفحات 115- 121
تاریخ انتشار 2013-03-02
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