Serum Adiponectin and Vaspin levels in Abdominal Obesity and Type 2 Diabetes Mellitus

Abstract Objective: Adiponectin and vaspin are adipocyte-derived proteins and involved in the regulation of glucose metabolism and obesity related disorders. The mechanisms that adipokines might be linked to disturbance of glucose are unclear. Thus, this study investigated the levels of serum adiponectin and vaspin, blood lipid profiles, and abdominal obesity in type 2 diabetes (T2DM) patients and controls. Materials and Methods: Frothy T2DM patients and 40 healthy volunteers matched by age and body mass index (BMI) were enrolled in the study. The levels of serum adiponectin, vaspin, fasting blood glucose (FBG), 2-hr post prandial (2hr-PP), and lipid profile were measured in both groups. Anthropometric parameters including BMI, waist circumference (WC) and waist to height ratio (WHR) were measured. Results: Higher levels of vaspin and lower levels of circulating adiponectin were observed in T2DM patients than in the controls (P-value:0.0001). In multivariate regression analyses adjusted for age and BMI, serum adiponectin levels showed a significant negative correlation with WC, WHR, FBG and duration of diabetes, and a positive correlation with HDL. While, the vaspin levels were positively correlated with WC, WHR and duration of diabetes in T2DM patients. In addition, vaspin and adiponectin levels had negative correlation with each other. Conclusion: The findings suggested that the abdominal obesity had the highest relationship with adiponectin and vaspin in diabetic patients.