Soluble E-selectin and P-Selectin Serum Levels in Patients with Psoriasis Compared to Healthy Controls
نویسندگان
چکیده مقاله:
Introduction: Psoriasis is an inflammatory skin disease in which abnormal individual immune reactivity plays an important role. Eselectin and P-selectin are adhesion molecules expressed on vascular endothelial cells in several inflammatory skin diseases, including psoriasis. The aim of the present study was to describe selected immunological changes, concerning adhesion molecules status (sEselectin, sP-selectin), in psoriasis and also their correlation with disease activity. Method: Serum levels of soluble E-selectin and soluble P-selectin were measured by enzyme-linked immunosorbent assay in 58 patients with psoriasis and 24 healthy control subjects. The relationships between these adhesion molecules and the Psoriasis Areaand Severity Index score were investigated. Result: There was a significant correlation between the serum soluble E-selectin levels and Psoriasis Area and Severity Index score. Conclusion: Soluble E-selectin serum levels correlate with the extent of psoriatic lesions and could be used as marker of the disease activity in psoriatic patients but this finding needs further modification.
منابع مشابه
Levels of Serum Soluble P-Selectin and E-Selectin in Psoriatıc Patients
Vol. 26 No. 2, 2014 275 Received January 3, 2013, Revised April 6, 2013, Accepted for publication May 14, 2013 *Recep Kesli is now with Department of Microbiology, Afyon University Faculty of Medicine, Afyonkarahisar, Turkey. Corresponding author: Arzu Ataseven, Department of Dermatology, Konya Training and Research Hospital, Meram, Konya 42090, Turkey. Tel: 90-0 505 691 58 59, Fax: 90-0 332 32...
متن کاملIncreased levels of soluble adhesion molecules, E-selectin and P-selectin, in patients with infective endocarditis and embolic events.
AIMS Inflammation-induced procoagulant changes and endothelial cell activation appear to play an important role in thromboembolic complications of infective endocarditis. Hence, the aim of this study was to compare the plasma levels of soluble adhesion molecules E- and P-selectin in infective endocarditis patients with and without embolic events, and healthy subjects. METHODS AND RESULTS The ...
متن کامل[Soluble P-selectin levels in synovial fluid and serum from patients with psoriatic arthritis].
OBJECTIVE P-selectin is an adhesion molecule expressed by activated endothelial cells and platelets favouring the leukocyte adherence to microvascular endothelium. A soluble form of this molecule has been described, whose serum levels were found to be elevated and correlate with disease activity in rheumatoid arthritis (RA) patients. Aim of this study was to determine soluble P-selectin levels ...
متن کاملIncreased levels of soluble P-selectin in hypercholesterolemic patients.
BACKGROUND Hypercholesterolemia is considered a major risk factor for the development of atherosclerosis. Enhanced lipid peroxidation and persistent platelet activation can be observed in vivo in hypercholesterolemic patients and may have pathophysiological implications in the occurrence of cardiovascular events. P-selectin may play an important role in the pathogenesis of multicellular events,...
متن کاملPlatelet P-Selectin Levels in Relation to Plasma Soluble P-Selectin and -Thromboglobulin Levels in Atrial Fibrillation
Background and Purpose—The increased risk of stroke and thromboembolism in atrial fibrillation (AF) may be related to a prothrombotic or hypercoagulable state, with abnormalities of hemostasis and platelet activation. To investigate the role of platelets in AF and the influence of antithrombotic therapy, we developed and then applied a new assay to detect the absolute amount of P-selectin per p...
متن کاملPlatelet P-selectin levels in relation to plasma soluble P-selectin and beta-thromboglobulin levels in atrial fibrillation.
BACKGROUND AND PURPOSE The increased risk of stroke and thromboembolism in atrial fibrillation (AF) may be related to a prothrombotic or hypercoagulable state, with abnormalities of hemostasis and platelet activation. To investigate the role of platelets in AF and the influence of antithrombotic therapy, we developed and then applied a new assay to detect the absolute amount of P-selectin per p...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ذخیره در منابع من قبلا به منابع من ذحیره شده{@ msg_add @}
عنوان ژورنال
دوره 13 شماره 1
صفحات 9- 11
تاریخ انتشار 2010-04-01
با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.
کلمات کلیدی
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023