Soluble Mediators in Posttraumatic Wrist and Primary Knee Osteoarthritis

نویسندگان

  • Arnold H. Schuurman Department of Plastic Reconstructive and Hand Surgery University Medical Center, Utrecht, the Netherlands
  • Gerjo V.M. Van Osch Department of Orthopedics & Department of Otorhinolaryngology Erasmus MC, University Medical Center, Rotterdam, The Netherlands
  • L. Paul van Minnen Department of Plastic Reconstructive and Hand Surgery University Medical Center, Utrecht, the Netherlands
  • Laura B. Creemers Department of Orthopedic Surgery University Medical Center, Utrecht, the Netherlands
  • Michiel Beekhuizen Department of Orthopedic Surgery University Medical Center, Utrecht, the Netherlands
  • Teun Teunis Department of Plastic Reconstructive and Hand Surgery University Medical Center, Utrecht, the Netherlands
چکیده مقاله:

Background:  New discoveries about the pathophysiology changed the concept that all forms of osteoarthritis are alike; this lead to the delineation of different phenotypes such as age, trauma or obese related forms. We aim to compare soluble mediator profiles in primary knee and posttraumatic wrist osteoarthritis. Based on the general faster progression rate of wrist osteoarthritis, we hypothesize a more inflammatory profile. Methods: We collected synovial fluid from 20 primary osteoarthritic knee and 20 posttraumatic osteoarthritic wrist joints. 17 mediators were measured by multiplex enzyme-linked immunosorbent assay: chemokine ligand 5, interferon-γ, leukemia inhibitory factor, oncostatin-M, osteoprotegerin, tumor necrosis factor-α, vascular endothelial growth factor, interleukin (IL)-1α, IL-1β, IL-1 receptor antagonist, IL-4, IL-6, IL-7, IL-8, IL-10, IL-13 and IL-17. Results:  Ten mediators were higher in posttraumatic osteoarthritic synovial fluid: tumor necrosis factor-α (TNFα), IL-1α, IL-1RA, IL-6, IL-10, IL-17, oncostatin-M, interferon-γ, chemokine ligand 5 and leukemia inhibitory factor(P

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

soluble mediators in posttraumatic wrist and primary knee osteoarthritis

background:  new discoveries about the pathophysiology changed the concept that all forms of osteoarthritis are alike; this lead to the delineation of different phenotypes such as age, trauma or obese related forms. we aim to compare soluble mediator profiles in primary knee and posttraumatic wrist osteoarthritis. based on the general faster progression rate of wrist osteoarthritis, we hypothes...

متن کامل

Evaluation of clinical symptoms and sonographic characteristics of femoral trochlear cartilage in primary knee osteoarthritis

Objective: This study was designed to evaluate the clinical symptoms and sonographic characteristics of femoral trochlear cartilage in patients with knee joint osteoarthritis (OA). Methods: This cross-sectional study was conducted on 94 patients with painful primary knee OA according to the American College of Rheumatology criteria with a visual analog scale pain score of 30 mm or more. Clinica...

متن کامل

Knee osteoarthritis: Therapeutic alternatives in primary care

AIM To discusses pharmacological and non-pharmacological therapeutic alternatives for managing knee osteoarthritis in primary care by primary health care nurse practitioners. METHODS A case example is presented, the evidence-based guideline recommendations of the Osteoarthritis Research Society International and the American Academy of Orthopaedic Surgeons are reviewed, and a plan of care is ...

متن کامل

New developments in osteoarthritis. Prevention of injury-related knee osteoarthritis: opportunities for the primary and secondary prevention of knee osteoarthritis

Where risk factors have been identified in knee and hip osteoarthritis (OA), with few exceptions, no prevention strategies have proven beneficial. The major risk factors for knee OA are advanced age, injury and obesity. However, there is limited or no evidence that they are modifiable or to what degree modifying them is effective in preventing development of knee OA or in preventing symptoms an...

متن کامل

Ankle rotation changes and its influences in knee osteoarthritis

  Background : Biomechanical factors are known to be important in knee osteoarthritis (OA) development and progression. This study was designed to determine changes of hamstrings muscle activation, knee adduction moment and ankle rotation angle in two knee osteoarthritis (mild and moderate) and a healthy control group.   Methods: 16 females (10 with mild and 6 with moderate medial knee osteoart...

متن کامل

Osteoarthritis of the wrist.

Osteoarthritis of the wrist is one of the most common conditions encountered by the orthopaedic surgeon and requires careful analysis and specific indications and rationale for appropriate treatment. Radiographic analysis and surgical approaches for reconstruction of the wrist consist of technical caveats that will improve outcome, including limited wrist fusions, proximal row carpectomy, and t...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


عنوان ژورنال

دوره 2  شماره 3

صفحات  146- 150

تاریخ انتشار 2014-09-01

با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023