Study of anti-yeast effects of Securigera Securidaca (L.) extracts microemulsion on Candida strains

Introduction: Candida infections constitute a large group of diseases, so today the need for low-harm antifungal agents is felt more than ever. Securigera Securidaca L. is a medicinal plant with antimicrobial, anti-pest, anti-parasitic and anti-fungal properties. Therefore, the aim of this study was to determine the anti-candida effects of microemulsion of ethanolic and methanolic extracts of Securigera Securidaca on different strains of Candida. Materials and Methods: In this laboratory study, ethanolic and methanolic extracts of Securigera Securidaca and twin 80 were used to make microemulsions. After examining the physicochemical characteristics (viscosity and pH), the well diffusion method was used to investigate the anti-yeast effect of the formulation on Candida strains. Results: Microemulsions in concentrations of 0.01% of Securigera Securidaca extracts showed significant anti-candidal properties. These microemulsions had the highest inhibitory effect against Candida albicans. Conclusion: Synthesized microemulsions based on Securigera Securidaca plant extract have good stability and showed high anti-yeast properties against Candida strains.