Terpenoid Compounds and Anti- Hemozoin and Anti- Ciliates Protozians Effects of Artemisia annua L. and Chenopodium botrys L.
Background: β-Hematin (Hemozoin) was synthised inside human erythrocyte by malaria parasite. The parasite avoids the toxic effects by polymerizing heme molecules into insoluble crystalline β-Hematin. C. botrys and A. annua used for the treatment of diseases like malaria, hepatitis, cancers, and inflammations. Objective: Determine of antimalarial and anti-protozoa effects of A. anuuae and C. botrys. Method: C. botrys and A. annua terpenoids were extracted by acetonitrile. The antimalarial activity of plant extracts was evaluated by in vitro β-Hematin formation. Some ciliates were tested by 0.01, 0.1 and 1 mgml-1 of C. botrys and A. annua extracts. Total terpenoid were measured by spectrophotometry method. The terpenoid extracts were determined by TLC and GC-MS. Results: Terpenoids effects on Paramecium and other ciliates was movement inhibition and cell targeting and cilia isolating induction and cell disjointing. Anti-malarial study on β-Hematin formation showed that acetonirile and aquatic extracts of shoots and roots of two species are antimalaria. Inhibiting effects of acetonirile and aquatic extracts of A. annua shoots were much of double effects of shoots of acetonirile extracts of C. botrys and aquatic extracts of A. annua root. Total terpenoids of two plants were 0.317- 4.46 mgg-1dw. TLC and GC/MS analysis showed that the acetonirile extract of A. annua contains artemisinin and several kinds of terpenoids, but in extracts of C. botrys with highe terpenoids content didn’t find artemisinin. Conclusion: The inhibiting effects of C. botrys on some ciliates and in vitro β-Hematin formation is from other terpenes in the extracts probably.
Anti-inflammatory, Antioxidant and Antimicrobial Effects of Artemisinin Extracts from Artemisia annua L.
The anti-inflammatory, antioxidant, and antimicrobial properties of artemisinin derived from water, methanol, ethanol, or acetone extracts of Artemisia annua L. were evaluated. All 4 artemisinin-containing extracts had anti-inflammatory effects. Of these, the acetone extract had the greatest inhibitory effect on lipopolysaccharide-induced nitric oxide (NO), prostaglandin E2 (PGE2), and proinfla...متن کامل
Shoot cultures of Artemisia annua L. were cultivated in three different micropropagation systems: an ultrasonic nutrient mist bioreactor (UNMB), a modified ultrasonic nutrient mist bioreactor (MUNMB) and solid culture in Magenta boxes. The shoots cultivated in the UNMB and MUNMB showed excellent growth. The dry weight increase (35 times) of shoot cultures in the MUNMB was higher than those (25 ...متن کامل
Uses Traditional and Artisanal Used traditionally in China to treat fevers and hemorrhoids. Used in the crafting of aromatic wreaths, as a flavoring for spirits such as vermouth, and as a source of essential oils for the perfume industry.متن کامل
A Review of Artemisia annua L.: Its Genetics, Biochemical Characteristics, and Anti-Malarial Efficacy
This paper presents a review on the genetics of A. annua as an important plant species for the treatment of malaria. A short history on the discovery of the plant is discussed. Furthermore, a clear description of the characteristics of A. annua is presented as the plant’s chemistry, mechanism of action and efficacy are thoroughly discussed. Many cytogenetic studies on A. annua focusing on the p...متن کامل
Anti-Plasmodial Polyvalent Interactions in Artemisia annua L. Aqueous Extract – Possible Synergistic and Resistance Mechanisms
Artemisia annua hot water infusion (tea) has been used in in vitro experiments against P. falciparum malaria parasites to test potency relative to equivalent pure artemisinin. High performance liquid chromatography (HPLC) and mass spectrometric analyses were employed to determine the metabolite profile of tea including the concentrations of artemisinin (47.5±0.8 mg L(-1)), dihydroartemisinic ac...متن کامل
Anti-tumour effects of polysaccharides isolated from Artemisia annua L by inducing cell apoptosis and immunomodulatory anti-hepatoma effects of polysaccharides.
BACKGROUND It is well known that various polysaccharides present anti-tumour effects by inducing cell apoptosis and immunomodulation. However, it is still unclear about the roles of polysaccharides isolated from Artemisia apiacea (HQG) to hepatoma and its underlying mechanism. The objective of the study was to examine the anti-hepatoma effects of HQG and its related mechanism. MATERIALS AND M...متن کامل
دوره 3 شماره 71
صفحات 49- 66
تاریخ انتشار 2019-09
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