Transdermal Delivery of Insulin by Biodegradable Chitosan Nanoparticles: Exvivo and In vivo Studies

نویسندگان

  • Jaya chandran SCS College of Pharmacy, Harpanahalli, Karnataka, India
  • Vijayan Venugopal Department of Biotechnology, Acharya Nagarjuna University, Guntur-522 510, Andhra, Pradesh, India
چکیده مقاله:

      Insulin-loaded biodegradable chitosan nanoparticle was prepared by the polyelec-trolyte complex formation method. The prepared nanoparticles were in the size of 110 nm and had high entrapment (91.0%) capacity. The transdermal nanoinsulin was characterized by in vivo hypoglycemic effects. Plasma glucose was decreased to the range of 80.34 to 96.74 mg/dl, and insulin levels were increased to the range of 21.62 to 45.80 µIU/ml for up to 60 h. The pharmacokinetic and pharmacodynamic parameters like AUC, Cmax, Tmax and relative bioavailability of transdermal patch loaded insulin-chitosan nanoparticles were 3153.36 µIU/ml/h, 45.80 µIU/ml, 8 h and 20.02%, respectively.

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transdermal delivery of insulin by biodegradable chitosan nanoparticles: exvivo and in vivo studies

insulin-loaded biodegradable chitosan nanoparticle was prepared by the polyelec-trolyte complex formation method. the prepared nanoparticles were in the size of 110 nm and had high entrapment (91.0%) capacity. the transdermal nanoinsulin was characterized by in vivo hypoglycemic effects. plasma glucose was decreased to the range of 80.34 to 96.74 mg/dl, and insulin levels were increased to the ...

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عنوان ژورنال

دوره 8  شماره 1

صفحات  315- 321

تاریخ انتشار 2012-01-01

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