Treatment of Malaria Parasitaemia in Infants and their Mothers
Malaria is an infection sustained by three parasites namely: Plasmodium falciparum, Plasmodium vivax, and Plasmodium ovale. Plasmodium falciparum is the most common and virulent parasite. These parasites are present in different areas of the sub-Saharan African countries and Asia. In 2010, there were an estimated 219 million cases of malaria resulting in 660,000 deaths and, approximately, two-thirds were children. In sub-Saharan African countries, maternal malaria is associated with up to 200,000 estimated infant deaths yearly. Chloroquine was the world's widely used antimalarial drug, but Plasmodium falciparum is now increasingly resistant. However, Plasmodium ovale and Plasmodium vivax are sensitive to chloroquine. Pregnancy makes women vulnerable to malarial parasites and the risks of anemia, miscarriage, stillbirth and prematurity increase. Resistance to chloroquine is a major concern for treatment of malaria and alternative drugs are needed. Proguanil is safe, being very rarely associated with severe adverse reactions. Chloroquine, mefloquine, sulfadoxine-pyrimethamine, and amodiaquine have been found to be active against Plasmodium falciparum in-vitro. In the Cameroons, chloroquine was initially replaced by amodiaquine and artemisinin-lumefantrine was gradually introduced in 2004. Tanzania replaced chloroquine with sulphadoxine-pyrimethamine, and in 2006 artemisinin was introduced in the therapy. Pyrimethamine-sulfadoxine should be reserved as a second-line-treatment. Mefloquine may provoke severe neuropsychiatric reactions. In the treatment of Plasmodium malaria, which has a high mortality rate if untreated, a greater risk of adverse reactions to malarial drugs is acceptable. The aim of the present study is to review the published data on the treatment of malaria in infants and their mothers.
Records of 402 children--2l6 (53.7%) males and l86 (46.3%) females--aged 1-36 month(s), admitted to the Diarrhoea Treatment and Training Unit of the University of Benin Teaching Hospital, Benin city, Nigeria, during July 1993-June 1996, were reviewed to document the relationship between dehydration and malaria parasitaemia. There was a significant association between severity of dehydration and...متن کامل
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Background & Aims: The purpose of the present study was to compare feeding problems, infant eating behavior, and feeding styles between infants with and without feeding problems according to their mothers’ narratives. Methods: In this casual-comparative study, 50 mother-infant dyads were selected using convenient sampling. The infants’ ages ranged between 6 to 12 months. After matching, the inf...متن کامل
دوره 6 شماره 3
صفحات 7311- 7343
تاریخ انتشار 2018-03-01
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