Moslem Najafi
Research Center for Medical Education, Tabriz University of Medical Sciences, Tabriz, IRAN
[ 1 ] - The Attitude of Medical Students of Tabriz University of Medical Sciences towards the Necessity of Clinical Pharmacology
Background: At the present time, teaching pharmacology for medical students mainly focuses on the basic principles of pharmacology. This study was conducted to assess the current situation of pharmacology teaching and the necessity of developing clinical pharmacology from the viewpoint of medical interns and externs in Tabriz University of Medical Sciences. Methods: This descriptive cross-secti...
[ 2 ] - Traditional and Modern Uses of Natural Honey in Human Diseases: A Review
Honey is a by-product of flower nectar and the upper aero-digestive tract of the honey bee, which is concentrated through a dehydration process inside the bee hive. Honey has a very complex chemical composition that varies depending on the botanical source. It has been used both as food and medicine since ancient times. Human use of honey is traced to some 8000 years ago as depicted by Stone ...
[ 4 ] - Effects of Acetyl-L-Carnitine on Cardiac Arrhythmias and Infarct Size in Ischemic-Reperfused Isolated Rat Heart
Objective(s) This study aimed to examine whether acetyl-L-carnitine (ALC) was able to reduce cardiac arrhythmias and infarct size in the ischemic-reperfused isolated rat heart. Materials and Methods The isolated hearts were mounted on a Langendorff apparatus then perfused by a modified Krebs-Henseleit solution during 30 min regional ischemia and 120 min reperfusion (control) or by enriched K...
[ 5 ] - The Impact of Gender on the Inflammatory Parameters and Angiogenesis in the Rat Air Pouch Model of Inflammation
Objective(s) Air pouch is a well-established inflammatory model in which fluid extravasations; leukocyte migration, angiogenesis and other parameters involved in the inflammatory response can be measured. In this study, the influence of gender on inflammatory parameters has been examined in the air pouch model. Materials and Methods To induce air pouch, adult male and female Wistar rats were...
[ 6 ] - Effects of Total Extract of Dracocephalum moldavica on Ischemia/Reperfusion Induced Arrhythmias and Infarct Size in the Isolated Rat Heart
Objective(s) Dracocephalum moldavica (D. moldavica) have been traditionally used as a cardiotonic agent in the folk medicine of some regions of Iran. In the present study, effects of total extract of D. moldavica on ischemia/reperfusion induced arrhythmias and infarct size investigated in isolated rat heart. Materials and Methods The isolated hearts were mounted on a Langendorff apparatus th...
[ 7 ] - Role of Fructose as a Potent Antiarrhythmic and Anti-infarct agent in Isolated Rat Heart
In the current study, effects of acute short term administration of fructose on cardiac arrhythmias and myocardial infarction size following ischemia/reperfusion were investigated in isolated rat heart. The hearts were subjected to 30 min zero flow global ischemia followed by 120 min reperfusion. In the control group, the hearts were perfused by normal drug free Krebs-Henseleit (K/H) solution t...
[ 8 ] - Role of Fructose as a Potent Antiarrhythmic and Anti-infarct agent in Isolated Rat Heart
In the current study, effects of acute short term administration of fructose on cardiac arrhythmias and myocardial infarction size following ischemia/reperfusion were investigated in isolated rat heart. The hearts were subjected to 30 min zero flow global ischemia followed by 120 min reperfusion. In the control group, the hearts were perfused by normal drug free Krebs-Henseleit (K/H) solution t...
[ 9 ] - Comparison between the effects of L-Carnitine and Acetyl-L-Carnitine on myocardial infarction size in ischemic heart
Introduction: In the present study, potential differences between the effects of L-carnitine (LC) and acetyl-Lcarnitine (ALC) on ischemia/reperfusion (I/R)-induced myocardial infarction size were investigated. Methods: Male Wistar rats were randomly divided into five groups and then anesthetized by sodium pentobarbital. Hearts of the animals were removed and quickly mounted on a Langendorff ...
[ 10 ] - Protective effect of pharmacologic postconditioning with Natural Honey against left ventricular ischemia/reperfusion-induced arrhythmias in isolated heart of rat
Introduction: This study was aimed to investigate the effects of postconditioning by natural honey on cardiac arrhythmias in the ischemic isolated rat heart. Methods: Male Wistar rats were divided into four groups then anesthetized by sodium pentobarbital. The animal hearts were removed and quickly mounted on a Langendorff apparatus and perfused under constant pressure by a modified Krebs-H...
[ 11 ] - Protective effect of natural honey applied during ischemia and reperfusion on infarct size in ischemic heartheart
Introduction: In the current study, protective effect of natural honey applied during ischemia/reperfusion (I/R) was studied on infarct size in ischemic heartheart. Methods: Ischemic hearthearts (n=8 per group) were mounted on a Langendorff apparatus at constant pressure then subjected to 30 min regional ischemia followed by 120 min reperfusion. In control group, the hearts were perfused by ...
[ 12 ] - Effects of L-Carnitine on Cardiac Apoptosis in Ischemic- Reperfused Isolated Rat Heart
Carnitine is a vital biologic substance for transporting fatty acids into myocytes. It also facilitates fatty acids β-oxidation for energy production. In this study, effects of L-carnitine (L-Car) on apoptosis in the ischemic isolated rat heart were investigated. Male Sprague-Dawley rats were divided into four groups and anesthetized by sodium pentobarbital. The heart was removed and mount...
[ 13 ] - Pharmacy Students’ Attitude in Tabriz University of Medical Sciences toward Using Computerized Simulations in Teaching
Introduction::Using computerized simulation is one of the new methods in medical education. However, there is no report on applying this technique for teaching pharmacology in Iran. This study was conducted to assess the attitude of pharmacy students toward using this method in the teaching of practical pharmacology. Methods: This descriptive–cross sectional study was performed on pharmacy stu...
[ 14 ] - Awareness and Satisfaction of Patients with Iranian Patient Package Inserts
Background and purpose: A drug brochure or Patient Package Insert (PPI) is a folded sheet of paper in drug package that provides necessary information for effective and safe use of the drug. PPIs are one of the main sources of drug information, so, they should be clear and easily comprehensible to the general public. The purpose of this study was to determine the awareness and satisfaction of p...
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