Nasrin Ziamajidi
Department of Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
[ 1 ] - Effects of insulin-loaded chitosan-alginate nanoparticle on RAGE expression and oxidative stress status in the kidney tissue of rats with type 1 diabetes
Objective(s): Chronic hyperglycemia leads to activation of the advanced glycation end products (AGE)-receptor (RAGE) for AGE axis and oxidative stress, which promote diabetic renal damage. This study examines the effect of insulin-loaded trimethyl chitosan nanoparticles on the kidney tissue of diabetic rats. Materials and Methods: Twenty-five male Wistar rats were randomly divided into 5 groups...
[ 2 ] - بررسی میزان بیان ژنهای Bax وBcl-2 و فعالیت آنزیم کاسپاز 3 در بافت کبد رتهای نرمال، دیابتی نوع 1 و 2 قبل و بعد از درمان با عصاره آبی سیر
Introduction: One of the complications of diabetes mellitus is induction of apoptosis in liver tissues. Activation of caspase 3 caused apoptosis in the cells. Garlic is a most common plant in diet that its effect on apoptosis was not determined. In this study the effects of this extract on Bax and Bcl-2 gene expression and the activity of caspase 3, were determined in type 1 and 2 of diabetes i...
[ 3 ] - Investigating Anticancer Effects of Silver Nanoparticles on Bladder Cancer 5637 Cells in Comparison to Human Embryonic Kidney Normal Cells (HEK-293)
Background & aim: Nanotechnology is a modern research field with broad applications in cancer management. Among the various metal nanoparticles, silver nanoparticles (AgNPs) have been used in cancer therapy due to their promising anti-tumor properties. Despite the great advantages of AgNPs, their effects on normal cells have become a challenge. Besides, their anti-cancer effects have not previo...
[ 4 ] - Aqueous Garlic Extract Alleviates Oxidative Stress and Inflammation in Retinal Tissue of Rats with Diabetes Type 2
Background and Objective: Retinopathy is a common difficulty in diabetic subjects. Hyperglycemia damages the tissues through stimulation of oxidative stress and inflammation. Since the antioxidant function of garlic has been proven, in the current report the activity of aqueous garlic extract (AGE) upon the oxidative stress and inflammation in the retinal substances of rats with diabetes was in...
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