Mohammad Javad Khoushnoud
Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
[ 1 ] - Effect of vitamins B1, B6 and B12 (Neurobion) on diisopropylfluorophosphate–induced delayed neuropathy in mice
Certain organophosphorus esters such as diisopropylfluorophosphate (DFP) cause delayed neuropathy by inhibition of neuropathy target esterase (NTE) keeping neuron in normal function. In this study, effects of neurobion alone and in combination with dexamethasone on DFP–induced delayed neuropathy were evaluated. Thirty-five mice were divided to five groups that each group consists 7 mice. Except...
[ 2 ] - Anticonvulsant Activity of Teucrium polium Against Seizure Induced by PTZ and MES in Mice
Teucrium polium (Labiatae) is a plant that widely grows in Iran. Some of species of Teucrium are used for a considerable range of actions in traditional medicine and T. polium has frequently been used as anticonvulsant. In this study, we investigated the protective effects of T. polium ethanolic aqueous extracts and related fractions on seizures induced by pentylenetetrazole (PTZ) and maximal e...
[ 3 ] - Effect of vitamins B1, B6 and B12 (Neurobion) on diisopropylfluorophosphate–induced delayed neuropathy in mice
Certain organophosphorus esters such as diisopropylfluorophosphate (DFP) cause delayed neuropathy by inhibition of neuropathy target esterase (NTE) keeping neuron in normal function. In this study, effects of neurobion alone and in combination with dexamethasone on DFP–induced delayed neuropathy were evaluated. Thirty-five mice were divided to five groups that each group consists 7 mice. Except...
[ 4 ] - Anticonvulsant Activity of Teucrium polium Against Seizure Induced by PTZ and MES in Mice
Teucrium polium (Labiatae) is a plant that widely grows in Iran. Some of species of Teucrium are used for a considerable range of actions in traditional medicine and T. polium has frequently been used as anticonvulsant. In this study, we investigated the protective effects of T. polium ethanolic aqueous extracts and related fractions on seizures induced by pentylenetetrazole (PTZ) and maximal e...
[ 5 ] - بررسی اثرات اسانس گیاه مرو تلخ (Salvia mirzayanii) بر یادگیری و حافظه موش سوری در آزمون یادگیری اجتنابی غیر فعال
سابقه و هدف: در طب سنتی گیاهان مختلفی از جمله گیاهان خانواده مریم گلی برای درمان فراموشی استفاده می شوند. گیاهان این خانواده دارای اثرات گوناگون فارماکولوژیکی از جمله آنتیاکسیدانی، آنتیکولین استرازی، ضد میکروبی، ضد التهابی بوده و دارای خاصیت بهبود شناخت و حافظه می باشند. گیاه مرو تلخ یکی از گونههای مریمگلی است که از گذشته کاربردهای دارویی داشته است. هدف از این مطالعه بررسی اثرات غلظتها...
[ 6 ] - Therapeutic Drug Monitoring of Sirolimus,Correlation With Laboratory Parameters In Transplant Patients
Sirolimus is a potent immunosuppressive agent administered as prophylactic agent to prevent rejection after organ transplantation. Sirolimus must be used within a narrow therapeutic window. Due to inter- and intra-variability, sirolimus blood concentrations may be affected, therefore, there is no possibility of predicting the sirolimus blood concentrations based on the dose patients received. T...
[ 7 ] - Effect of Simvastatin on Cisplatin-induced Nephrotoxicity in Male Rats
Statins have antioxidant and anti-inflammatory effects that are not directly related to their cholesterol-lowering activity. This study aimed to investigate the effect of simvastatin on the extent of tissue damage in cisplatin-induced nephrotoxicity. Simvastatin was orally given to rats in different doses (1, 2 and 4 mg/kg), 1 h prior to cisplatin injection (5 mg/kg, i.p.). All animals we...
[ 8 ] - Heavy Metals (Zn, Cu, Pb, Cd and Hg) Contents and Fatty Acids Ratios in Two Fish Species (Scomberomorus commerson and Otolithes ruber) of the Persian Gulf
This study was conducted to determine the concentrations of metals (Zn, Cu, Pb, Cd and Hg) in two commercial fish species of the Persian Gulf (coast of Bushehr Province in Iran), as well as in the sea waters. The concentrations of metals were determined by using differential pulse anodic stripping voltammetry (DPASV). Two selected species were narrow-barred Spanish mackerel and tiger toot...
[ 9 ] - بررسی اثر ضدالتهابی داروی سدیم والپروات با استفاده از مدل کاراژینان در موش صحرایی نر
چکیده: مقدمه و هدف: التهاب پاسخ دفاعی بدن به محرک‌های خارجی و داخلی از قبیل؛ مواد شیمیایی، اشعه، آسیب و میکروارگانیسم‌های مهاجم می‌باشد که منجر به درد و تخریب بافتی و نهایتاً اختلال در کیفیت زندگی بیمار می‌گردد. امروزه کنترل و درمان التهاب از اهمیت زیادی برخورداراست و از داروهای صناعی و طبیعی زیادی برای درمان آن استفاده می‌شود و ترکیبات بسیاری هم در حال مطالعه و بررسی می‌باشد. هدف از این تحق...
[ 10 ] - The Protective Effect of Nortriptyline Against Gastric Lesions Induced by Indomethacin and Cold-shock Stress in Rats
Background: Gastric ulcer is among the most serious stomach disorder universally. Several effective drugs are employed in the management of this disease, although there have been adverse effects in some cases. The aim of this study was to investigate the effect of nortriptyline to protect against gastric lesions, induced by indomethacin or cold-stress in rats. Methods: Gastric lesions were ind...
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