Amir Jalali
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[ 1 ] - Impact of Pharmaceutical Impurities in Ecstasy Tablets: Gas Chromatography-Mass Spectrometry Study
In this study, a simple and reliable method by gas chromatograph–mass spectrometry (GC–MS) was developed for the fast and regular identification of 3, 4-MDMA impurities in ecstasy tablets. In so doing, 8 samples of impurities were extracted by diethyl ether under alkaline condition and then analyzed by GC–MS. The results revealed high MDMA levels ranging from 37.6% to 57.7%. The GC-MS method sh...
[ 2 ] - Epidemiological review of scorpion envenomation in Iran
This epidemiological review was carried out to display the magnitude and the geographic distribution of scorpion envenomation in Iran with focus on the southwestern region of Iran, particularly. The Iranian recognized scorpions belonging to two families, including Buthidae and Scorpionidae. Buthidae family consists of 14 genuses, 26 species, and 18 sub-species, while Scorpionidae family has thr...
[ 3 ] - Dosage Comparison of Snake Anti-venom on Coagulopathy
This study was done to determine whether high or low dose of anti-snake venom (ASV) is better in coagulopathy in victims of envenoming by vipers. This retrospective study was conducted on the 154 patients (Mean age ± SD, Range) of viper snake bites who were referred to the emergency ward of Razi Hospital, Ahvaz, Iran over 2 years period (2004 - 2006). According to the treatment dosage the patie...
[ 4 ] - Effects of Odontobuthus Doriae Scorpion Venom on Mouse Sciatic Nerve
Temporary paralysis is a rare manifestation of envenoming following the yellow Iranian scorpion, Odontobuthus doriae (O. doriae). Thus, to elucidate the underlying mechanism, we investigated the neurotoxic effect of venom in the sciatic nerve, the possible mechanism in a mice model. The neurotoxicity and temperature effects in the venom-induced neurotoxicity were examined using the mouse sciati...
[ 5 ] - Cytotoxic Effects of two Iranian Scorpions Odontobuthusdoriae and Bothutus saulcyi on Five Human Cultured Cell lines and Fractions of Toxic Venom
Scorpion venom toxicity is of major concern due to its influence on human activities and public health. We investigated the in-vitro process of cell death caused by two Iranian scorpions Odontobuthus doriae and Bothutus salceyi venom on human cell lines. The aim of this study was to provide further information about triggering cell death and suggestion of methods for the elimination of unwanted...
[ 6 ] - Curative effects of Cassia fistula fruit extract on bromobenzene-induced hepatotoxicity and nephrotoxicity in mice
Background & objectives: The present investigation was designed to evaluate the post-treatment properties of the hydroalcoholic fruit extract of cassia fistula (golden shower tree) in male Albino mice. Materials & Methods: Biomarkers and histological liver and kidney alterations, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (...
[ 7 ] - Impact of Pharmaceutical Impurities in Ecstasy Tablets: Gas Chromatography-Mass Spectrometry Study
In this study, a simple and reliable method by gas chromatograph–mass spectrometry (GC–MS) was developed for the fast and regular identification of 3, 4-MDMA impurities in ecstasy tablets. In so doing, 8 samples of impurities were extracted by diethyl ether under alkaline condition and then analyzed by GC–MS. The results revealed high MDMA levels ranging from 37.6% to 57.7%. The GC-MS method sh...
[ 8 ] - Epidemiological review of scorpion envenomation in Iran
This epidemiological review was carried out to display the magnitude and the geographic distribution of scorpion envenomation in Iran with focus on the southwestern region of Iran, particularly. The Iranian recognized scorpions belonging to two families, including Buthidae and Scorpionidae. Buthidae family consists of 14 genuses, 26 species, and 18 sub-species, while Scorpionidae family has thr...
[ 9 ] - Dosage Comparison of Snake Anti-venom on Coagulopathy
This study was done to determine whether high or low dose of anti-snake venom (ASV) is better in coagulopathy in victims of envenoming by vipers. This retrospective study was conducted on the 154 patients (Mean age ± SD, Range) of viper snake bites who were referred to the emergency ward of Razi Hospital, Ahvaz, Iran over 2 years period (2004 - 2006). According to the treatment dosage the patie...
[ 10 ] - Effects of Odontobuthus Doriae Scorpion Venom on Mouse Sciatic Nerve
Temporary paralysis is a rare manifestation of envenoming following the yellow Iranian scorpion, Odontobuthus doriae (O. doriae). Thus, to elucidate the underlying mechanism, we investigated the neurotoxic effect of venom in the sciatic nerve, the possible mechanism in a mice model. The neurotoxicity and temperature effects in the venom-induced neurotoxicity were examined using the mouse sciati...
[ 11 ] - Cytotoxic Effects of two Iranian Scorpions Odontobuthusdoriae and Bothutus saulcyi on Five Human Cultured Cell lines and Fractions of Toxic Venom
Scorpion venom toxicity is of major concern due to its influence on human activities and public health. We investigated the in-vitro process of cell death caused by two Iranian scorpions Odontobuthus doriae and Bothutus salceyi venom on human cell lines. The aim of this study was to provide further information about triggering cell death and suggestion of methods for the elimination of unwanted...
[ 12 ] - تعیین فراوانی آللی و ژنوتیپی پلی‌مورفیسم B5*1E2CYP در جمعیت عمومی جنوب غرب ایران
زمینه: سیتوکروم 1E4502P(1E2CYP) آنزیمی اصلی است که نقش عمده‌ای در فعال‌سازی و سمیت‌زدایی بسیاری از ژنوبیوتیک‌ها، سرطان‌زاها (کارسینوژن‌ها) و داروها ایفا می‌کند. بررسی انواع پلی‌مورفیسم در 1E2CYP به‌عنوان یک ضرورت اولیه خطر ابتلا به انواع سرطان در صورت تماس با ترکیبات کارسینوژن، یافته‌های متفاوتی داشته است. هدف از این بررسی تعیین فراوانی آللی و ژنوتیپی پلی‌مورفیسم B5*1E2CYP در جمعیت ایرانی و مقا...
[ 13 ] - بررسی اثر جهش‌زایی عصاره‌ی متانولی گیاه گل گاوزبان (Echium amuenum) با تست ایمز (Ames bioassay)
زمینه: گیاه گل گاوزبان (Echium amuenum) دارای آلکالوئیدهای پیرولیزیدین با اثرات شناخته شده سمیت کبدی و موتاژنیسیته میباشد. بر همین اساس در این تحقیق اثرات جهش‌زایی احتمالی عصاره‌ی متانولی سر شاخه‌های گلدار آن، با استفاده از تست ایمز بررسی شد. مواد و روش‌ها: عصاره‌گیری با روش خیساندن در متانول به مدت 48 ساعت انجام شد. عصاره گیاه از نظر آلودگی به آفلاتوکسین B1 و حضور اسیدآمینه هیستیدین به‌روش TL...
[ 14 ] - First transcriptome analysis of Iranian scorpion, Mesobuthus eupeus venom gland
Scorpions are generally an important source of bioactive components, including toxins and other small peptides as attractive molecules for new drug development. Mesobuthus eupeus, from medically important and widely distributed Buthidae family, is the most abundant species in Iran. Researchers are interesting on the gland of this scorpion due to the complexity of its venom. Here, we have analyz...
[ 15 ] - First transcriptome analysis of Iranian scorpion, Mesobuthus eupeus venom gland
Scorpions are generally an important source of bioactive components, including toxins and other small peptides as attractive molecules for new drug development. Mesobuthus eupeus, from medically important and widely distributed Buthidae family, is the most abundant species in Iran. Researchers are interesting on the gland of this scorpion due to the complexity of its venom. Here, we have analyz...
[ 16 ] - Three new scorpion chloride channel toxins as potential anti-cancer drugs: Computational prediction of the interactions with hMMP-2 by docking and Steered Molecular Dynamics Simulations
Scorpion venom is a rich source of toxins which have great potential to develop new therapeutic agents. Scorpion chloride channel toxins (ClTxs), such as Chlorotoxin selectively inhibit human Matrix Methaloproteinase-2 (hMMP-2). The inhibitors of hMMP-2 have potential use in cancer therapy. Three new ClTxs, meuCl14, meuCl15 and meuCl16, derived from the venom transcriptome of Iranian scorpion, ...
[ 17 ] - Three new scorpion chloride channel toxins as potential anti-cancer drugs: Computational prediction of the interactions with hMMP-2 by docking and Steered Molecular Dynamics Simulations
Scorpion venom is a rich source of toxins which have great potential to develop new therapeutic agents. Scorpion chloride channel toxins (ClTxs), such as Chlorotoxin selectively inhibit human Matrix Methaloproteinase-2 (hMMP-2). The inhibitors of hMMP-2 have potential use in cancer therapy. Three new ClTxs, meuCl14, meuCl15 and meuCl16, derived from the venom transcriptome of Iranian scorpion, ...
نویسندگان همکار