Maliheh Entezari
[ 1 ] - Analysis of the antiproliferative effects of curcumin and nanocurcumin in MDA-MB231 as a breast cancer cell line
Cancer is one of the main cause of mortality in the world which appears by the effect of enviromental physico-chemical mutagen and carcinogen agents. The identification of new cytotoxic drug with low sid effects on immune system has developed as important area in new studies of immunopharmacology. Curcumin is a natural polyphenol with anti-oxidative, anti-inflammatory and anti-cancer properties...
[ 2 ] - Analysis of the antiproliferative effects of curcumin and nanocurcumin in MDA-MB231 as a breast cancer cell line
Cancer is one of the main cause of mortality in the world which appears by the effect of enviromental physico-chemical mutagen and carcinogen agents. The identification of new cytotoxic drug with low sid effects on immune system has developed as important area in new studies of immunopharmacology. Curcumin is a natural polyphenol with anti-oxidative, anti-inflammatory and anti-cancer properties...
[ 3 ] - بررسی خواص ضدجهشی و سایتوتوکسیک عصاره پوست سیب Malus domestica
سابقه و هدف: در حال حاضر سرطان یکی از علل عمده مرگ و میر در جهان است بنابراین از پیشگیری میتوان به عنوان مهمترین رویکرد درمانی سرطان درنظر گرفت. رژیم غذایی نقش مهمی در پیشگیری از سرطان بازی میکند. امروزه محققان توجه ویژهای به غذاهای طبیعی دارند که میتوانند به طور چشمگیری نقش پیشگیری از سرطان را داشته باشند. هدف از این تحقیق سنجش خواص ضدجهشی و ضدسرطانی عصاره پوست سیب بود. روش بررسی: در ای...
[ 4 ] - بررسی اثر آنتی اکسیدان یوبیکینون بر روی بیان ژن MCL1 سلولهای هرمی ناحیه CA1 هیپوکامپ متأثر از بازگشت مجدد جریان خون پس از ایسکمی
سابقه و هدف: هدف این مطالعه بررسی اثر آنتی اکسیدان یوبیکینون بر روی بیان ژن MCL1 سلولهای هرمی ناحیه CA1 هیپوکامپ متأثر از بازگشت مجدد جریان خون پس از ایسکمی بود. روش بررسی: در این مطالعه 24 موش صحرایی نر نژاد ویستار به وزن 300-250 گرم به طور تصادفی انتخاب و به 4 گروه کنترل (نگهداری در شرایط استاندارد آزمایشگاهی و جدا کردن هیپوکامپ از مغز موش)، ایسکمی (بستن شریان کاروتید به صورت دو طرفه و ایس...
[ 5 ] - Toxicity of Manganese Titanate on Rat Vital Organ Mitochondria
The TiO2, which is a main material in the field of photocatalytic reactions, includes rutile and anatase phase. Titanium dioxide has possessed notice due to its promising applications in the environmental photocatalytic degradation of pollutants of organic compound in waste water and utilization of solar energy. The nanosized manganese titanate (pyrophanite) MnTiO3 was collected by oxidation of...
[ 6 ] - Toxicity of Manganese Titanate on Rat Vital Organ Mitochondria
The TiO2, which is a main material in the field of photocatalytic reactions, includes rutile and anatase phase. Titanium dioxide has possessed notice due to its promising applications in the environmental photocatalytic degradation of pollutants of organic compound in waste water and utilization of solar energy. The nanosized manganese titanate (pyrophanite) MnTiO3 was collected by oxidation of...
[ 7 ] - Bad gene expression following effect of coenzyme Q10 on Wistar rat hippocampus with cerebral ischemia
Background: Q10 coenzyme is a potent antioxidant in the mitochondrial membrane. Releasing the oxygen free radicals occurs in the cerebral ischemia. Using Q10 coenzyme causes strength against oxidative after injury of cerebral ischemia during reperfusion. Also CoQ10 plays an important anti-apoptotic role to reduce Caspase 3 as a key enzyme neuroprotective in apoptosis. According to the sensitive...
[ 8 ] - Investigating FGF11 gene transcription level in cancer cells among colorectal cancer patients
Background: Colorectal cancer (CRC) is the fourth leading cause of cancer-caused death around the world. Reports of the unnecessary transcription of family genes of the fibroblast growth factor in several types of cancer indicate the role of these factors in tumorgenesis and progression of cancer. Therefore, the level of FGF11 transcription was evaluated in colorectal cancer tumor tissues relat...
[ 9 ] - Evaluation of neuroprotective effects of cobalamin (vitamin B12) in Parkinson's disease - Investigation of molecular mechanisms
Background & objectives: Parkinson's disease is one of the most common neurodegenerative diseases that its prevalence has increased in recent years. Although many efforts have been made to treat this disease, so far, no therapeutic approach has been found that can stop the destruction of dopaminergic cells in the substantia nigra. The aim of the present study was to investigate the effect of v...
[ 10 ] - Mesenchymal Stem Cells Trigger Epithelial to Mesenchymal Transition in the HT-29 Colorectal Cancer Cell Line
Background and Objective: Mesenchymal stem cells (MSCs) promote metastasis in colorectal cancer; however, the mechanism underlying this process is not fully understood. Epithelial to mesenchymal transition (EMT) is a key step in tumor acquisition of metastatic phenotype. We aimed to investigate the effect of MSCs on the expression of EMT markers, as well as cancer stem cell markers in HT-29 col...
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