Tourandokht Baluchnejadmojarad
Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, IR Iran.
[ 1 ] - Endothelium-dependent Effect of Sesame Seed Feeding on Vascular Reactivity of Streptozotocin-diabetic Rats: Underlying Mechanisms
Cardiovascular disorders continue to constitute major causes of morbidity and mortality in diabetic patients. In this study, the effect of chronic administration of sesame (Sesamum indicum L) seed feeding was studied on aortic reactivity of streptozotocin (STZ)-diabetic rats. Male diabetic rats received sesame seed-mixed food at weight ratios of 3% and 6% for 7 weeks, one week after diabetes in...
[ 2 ] - Chronic Oral Epigallocatechin-gallate Alleviates Streptozotocin-induced Diabetic Neuropathic Hyperalgesia in Rat: Involvement of Oxidative Stress
Due to the anti-diabetic and antioxidant activity of green tea epigallocatechin-gallate (EGCG), this research study was conducted to evaluate, for the first time, the efficacy of chronic treatment of EGCG on alleviation of hyperalgesia in streptozotocin-diabetic (STZ-diabetic) rats. Male Wistar rats were divided into control, diabetic, EGCG-treated-control and diabetic and sodium salicylate (SS...
[ 3 ] - Dipeptidyl peptidase-4 inhibitor ameliorates status epilepticus seizures and cognitive disturbances in a rat model of temporal lobe epilepsy
Background and Objective: In temporal lobe epilepsy (TLE), recurrent seizures accompany with cognitive deficit. In some patients, the current medications cannot provide satisfactory control of seizures, therefore new drugs that act through different mechanisms are required. In the present study, the useful effect of dipeptidyl peptidase-4 inhibitor was evaluated in experimental model of tempora...
[ 4 ] - Isorhamnetin mitigates learning and memory disturbances in streptozotocin-induced diabetic rats
Background and Objective: Diabetes as a metabolic disorder can cause memory and learning impairment. In recent years, the effect of plant extracts on the treatment of diabetes mellitus has been raised. The purpose of this study was to determine the effect of isorhmnetin administration on learning and memory disability in an experimental model of streptozotocin-induced diabetes mellitus in rats....
[ 5 ] - Salvianolic acid B improves insulin secretion from interleukin 1β-treated rat pancreatic islets: The role of PI3K-Akt signaling
Background and Objective: Oxidative stress induced by proinflammatory cytokines such as IL-1β plays a major role in β-cell destruction in diabetes type 1. Salvianolic acid B (Sal B) is a polyphenolic compound with antioxidant and protective effects. Thus, objective of this study was to assess the protection exerted by Sal B on isolated rat islets exposed to IL-1β and to investigate an underlyin...
[ 6 ] - The Effect of Hepatocyte Growth Factor on Learning and Memory Abilities in a Rat Model of Kainate-Induced Epilepsy
Background and Objective: Epilepsy as a chronic neurological disorder causes inherent seizures and learning and memory failure. Since there is no acceptable control of seizures in some patients with the current recommended drug therapy, new medications with different mechanisms of action are needed. Here, the beneficial effect of hepatocyte growth factor (HGF) was evaluated in an experimental m...
[ 7 ] - The Effect of Fibroblast Growth Factor 21 on a Cellular Model of Alzheimer's Disease with Emphasis on Cell Viability and Mitochondrial Membrane Potential
Background and Objective: Alzheimer’s disease (AD) is a neurodegenerative disorder which is associated with extracellular accumulation of amyloid beta (Aβ) plaques. AD is accompanied by mitochondrial dysfunction and energy metabolism reduction. Fibroblast growth factor 21 (FGF21) is an endogenous polypeptide which its beneficial effects have been demonstrated on mitochondrial function, energy m...
[ 8 ] - The beneficial effects of riluzole on GFAP and iNOS expression in intrahippocampal Aβ rat model of Alzheimer’s disease
Background and Objective: Alzheimer’s disease (AD) is a neurodegenerative disorder specified by deposition of b-amyloid (Ab) and neuronal loss that leads to learning and memory disturbances. One of the most important causes of AD is glutamate-dependent excitotoxicity in brain regions that is vulnerable to AD. According to previous reported results, it was revealed that riluzole, as a glutamate ...
[ 9 ] - The protective effect of carvacrol on kainic acid-induced model of temporal lobe epilepsy in male rat
Background and Objective: Temporal lobe epilepsy (TLE) is a chronic neurological disorder with spontaneous recurrent seizures and abnormal intracranial waves. Since the role of oxidative stress in the occurrence of epilepsy is inevitable, it seems that the use of antioxidants can prevent some of the complications resulting from this disease. This study was designed to assess the protective effe...
[ 10 ] - Salvianolic Acid Improves Status Epilepticus and Learning and Memory Deficiency in Rat Model of Temporal Lobe Epilepsy
Background and Objective: Epilepsy is a long-lasting central nervous system disorder that is accompany with spontaneous seizures and insufficiency in learning and memory. Now drug treatment is the most common therapy but some patients do not research to suitable control of their seizures with current drugs. Hence, new treatment is needed to help those patients that are unaffected to existing dr...
[ 11 ] - Protective Effect of Carvacrol in 6-hydroxydopamine Hemi-parkinsonian Rat Model
Background and Objective: A huge amount of investigational evidence support a role for oxidative stress as an intermediary of nerve cell dysfunction in Parkinson’s disease (PD). Polyphenols such as carvacrol have been indicated to prevent neuronal deterioration caused by increased oxidative load, thus, this study evaluated whether carvacrol administration would attenuate behavioral abnormalitie...
[ 12 ] - Administration of Salvianolic Acid B Attenuates Learning and Memory Deficits in Diabetic Rats: Involvement of Oxidative Stress
Background and Objective: Based on the effect of chronic metabolic diseases including diabetes mellitus on the learning and memory, this study was designed to assess the usefulness of administration of salvialonic acid B on lessening of learning and memory deficits in streptozotocin (STZ)-diabetic rats. Materials and Methods: Male Wistar rats were allocated into control, salvialonic acid B-trea...
[ 13 ] - Rosmarinic acid mitigates learning and memory disturbances in amyloid β(25–35)-induced model of Alzheimer’s disease in rat
Abstract Background and Objective: Alzheimer’s disease (AD) is a weakening neurodegenerative disorder typified by increased b-amyloid (Ab) deposition and neuronal dysfunction causing to impaired learning and memory. Among proposed risk factors, induced oxidative stress is a main cause for incidence of the disease. The aim of this study was to determine the effects of the rosmarinic acid on lear...
[ 14 ] - Endothelium-dependent Effect of Sesame Seed Feeding on Vascular Reactivity of Streptozotocin-diabetic Rats: Underlying Mechanisms
Cardiovascular disorders continue to constitute major causes of morbidity and mortality in diabetic patients. In this study, the effect of chronic administration of sesame (Sesamum indicum L) seed feeding was studied on aortic reactivity of streptozotocin (STZ)-diabetic rats. Male diabetic rats received sesame seed-mixed food at weight ratios of 3% and 6% for 7 weeks, one week after diabetes in...
[ 15 ] - Chronic Oral Epigallocatechin-gallate Alleviates Streptozotocin-induced Diabetic Neuropathic Hyperalgesia in Rat: Involvement of Oxidative Stress
Due to the anti-diabetic and antioxidant activity of green tea epigallocatechin-gallate (EGCG), this research study was conducted to evaluate, for the first time, the efficacy of chronic treatment of EGCG on alleviation of hyperalgesia in streptozotocin-diabetic (STZ-diabetic) rats. Male Wistar rats were divided into control, diabetic, EGCG-treated-control and diabetic and sodium salicylate (SS...
[ 16 ] - اثر حفاظتی تجویز دراز مدت سیلیمارین بر میزان گلوکز و لیپیدهای خون و استرس اکسیداتیو در موش صحرایی دیابتی
سابقه و هدف: کاهش دادن سطح استرس اکسیداتیو و میزان گلوکز و لیپیدهای نامطلوب سرم در بیماران دیابتی از اهمیت بالینی زیادی برخوردار است. در این مطالعه، تاثیر سیلیمارین بر میزان گلوکز، لیپیدهای خون و سطح استرس اکسیداتیو موش صحرایی دیابتی مورد بررسی قرار گرفت. مواد و روشها: در این مطالعه تحقیقاتی از نوع تجربی، موشهای صحرایی نر (40 =n) به طور تصادفی به چهار گروه کنترل، کنترل تحت تیمار با سیلیما...
[ 17 ] - اثر حفاظتی کوآنزیم Q10 برتشنج، حافظه فضایی کوتاه مدت و استرس اکسیداتیودر مدل صرع القا شده به وسیله اسیدکاینیک در موش صحرایی
زمینه و هدف:صرع لوب گیجگاهی شایعترین نوع صرع در انسان است. بیماران مبتلا به این نوع صرع از تشنجات غیرقابل کنترل و اختلال در حافظه رنج میبرند. این مطالعه برای ارزیابی اثر تجویز کوآنزیم Q10 بر تشنج، حافظه فضایی کوتاه مدت و برخی از شاخصهای استرس اکسیداتیو هیپوکامپ در صرع القا شده به وسیله اسیدکاینیک در موش صحرایی انجام شد. روش بررسی : در این مطالعه تجربی 48 سر موش صحرایی نر به شش گروه شم، گروه...
[ 18 ] - اثر تجویز دراز مدت سیلی مارین بر شاخصهای استرس اکسیداتیو بافت کلیه موش صحرایی نر دیابتی
زمینه و هدف : دیابت قندی موجب افزایش استرس اکسیداتیو و کاهش فعالیت سیستم دفاع آنتیاکسیدانتی میشود. با توجه به اهمیت تشدید استرس اکسیداتیو در بروز آسیب کلیوی در بیماری دیابت، این مطالعه به منظور ارزیابی اثر تجویز دراز مدت سیلی مارین بر شاخصهای استرس اکسیداتیو بافت کلیه موش صحرایی دیابتی انجام شد. روش بررسی : این مطالعه تجربی روی 40 سر موش صحرایی نر سفید نژاد ویستار با وزن تقریبی 300-240 گرم ...
[ 19 ] - نقش نیتریک اکساید و ذخایر داخل سلولی کلسیم در اثر حفاظتی عصاره آبی گیاه درمنه بر پاسخ انقباضی حلقه های آئورتی به آگونیست آلفا 1 - آدرنوسپتور در موشهای صحرایی دیابتی
Introduction & Objective: Vascular complications represent the main cause of mortality in diabetic patients. Considering the role of plants containing flavonoids in elimination of diabetic vascular disorders and the protective effect of the aqueous extract of Artemisia annua on aortic contractile response in diabetic rats, we evaluated the mechanism of vasodilating action of Artemisia annua ext...
[ 20 ] - بررسی اثر تجویز درازمدت سیلیمارین بر هیپرآلژزیای حرارتی و شیمیایی در مدل تجربی نوروپاتی دیابتی در موش صحرایی نر
مقدمه: هیپرآلرژی یکی از مشخصههای بارز نوروپاتی دیابتی است. با توجه به اثر هیپوگلیسمیک و آنتیاکسیدانی سیلیمارین، در مطالعهی حاضر اثر ضد درد سیلیمارین، در مدل تجربی نوروپاتی دیابتی در موشهای صحرایی نر بررسی شد. مواد و روشها: برای انجام آزمون Warm tail immersion، موشها به چهارگروه شاهد، دیابتی، کنترل و دیابتی تیمار شده با سیلیمارین تقسیم شدند. در آزمون فرمالین، به چهار گروه فوق دو گروه شا...
[ 21 ] - The Anticonvulsant and Antioxidant Effects of Berberine in Kainate-induced Temporal Lobe Epilepsy in Rats
Introduction: Temporal lobe epilepsy(TLE) is a long lasting neurological disorder in which patients suffer from spontaneous seizures. New treatments with novel mechanisms of action are needed to help those patients whose seizures are resistant to available drugs. In this study, we investigated the possible neuroprotective effect of berberine in an intrahippocampal kainate model of TLE in rat. M...
[ 22 ] - Green Tea Polyphenol Epigallocatechin-3-Gallate Attenuates Behavioral Abnormality in Hemi-Parkinsonian Rat
Background: Epigallocatechin gallate (EGCG), a major constituent of green tea, has been introduced as a potent free radical scavenger and can effectively reduce free radical-induced lipid peroxidation. Since free radical injury plays an important role in neuronal damage in Parkinson’s disease (PD), this study examined whether EGCG administration would reduce functional asymmetry in an experimen...
[ 23 ] - Effect of Subchronic Administration of Aqueous Artemisia annua Extract on a1-Adrenoceptor Agonist-Induced Contraction of Isolated Aorta in Rat
Artemisia species, growing in almost all the northern hemisphere, is used in folk medicine of some countries as a remedy for hypertension. Since some cardiovascular disorders including hypertension are accompanied with altered responsiveness of vascular alpha-adrenergic receptors, the effect of aqueous Artemisia annua extract (100 and 200 mg kg-1) on a1-adrenoceptor agonist-induced contraction ...
[ 24 ] - Effect of Subchronic Administration of Captopril on a1-Adrenoceptor Agonist-Induced Contraction of Isolated Aorta in Rat
Angiotensin II is a major endocrine hormone that affects directly both vascular smooth muscle and endothelial cells. Since vascular reactivity to angiotensin II changes in more physiological and pathophysiological conditions, the present study was performed to investigate the effect of intraperitoneal administration of angiotensin-converting enzyme inhibitor and captopril (30 and 50 mg kg-1, on...
[ 25 ] - Modification of Nifedipine Inhibitory Effect on Calcium Spike and L-Type Calcium Current by Ethanol in F1 Neuron of Helix aspersa
There is strong evidence demonstrating that nifedipine dissolved in ethanol selectively inhibits only L-type Ca2+ current. In addition, acute ethanol exposure reduces voltage-dependent calcium currents. In the present study, we investigated the antagonistic effect of fixed concentration of nifedipine dissolved in different concentration of ethanol on L-type Ca2+ current. In a Na+-K+ free soluti...
[ 26 ] - اثر تجویز دراز مدت سیلیمارین بر برخی شاخصهای آنزیمی و سطح بافتی مالون دیآلدئید در موش صحرایی دیابتی
Background and Aim: Diabetes mellitus causes enhanced oxidative stress due to increased production of oxygen free radicals and decreased activity of antioxidant defense system. Flavonolignan Silymarin has an antidiabetic effect. This study was conducted to evaluate the effect of its chronic administration on serum levels of aspartate and alanine aminotranferase and the heart and liver level of ...
[ 27 ] - The Association Between Circulating Klotho and Dipeptidyl Peptidase-4 Activity and Inflammatory Cytokines in Elderly Patients With Alzheimer Disease
Introduction: Klotho and dipeptidyl peptidase-4 (DPP4) are two proteins that modulate inflammatory pathways. We investigated the association between circulating klotho and DPP4 activity and their relationship with inflammatory cytokines, miR-29a, and miR-195 in Alzheimer disease (AD). Methods: This study was conducted on 16 AD patients and 16 healthy age-matched controls. Plasma levels of tumo...
[ 28 ] - Diabetic Encephalopathy Affects Mitochondria and Axonal Transport Proteins
Introduction: Diabetic encephalopathy is described as any cognitive and memory impairments and associated with hippocampal degenerative changes, include neurodegenerative process and decreased number of living cell. Mitochondrial Diabetes (MD) appears fallowing activation of mutant mitochondrial DNA and is combination of diabetes and cognitive deficit. In this research we showed the correlation...
[ 29 ] - Dalteparin as a Novel Therapeutic Agent to Prevent Diabetic Encephalopathy by Targeting Oxidative Stress and Inflammation
Introduction: Hepcidin is the principal modulator of systemic iron metabolism, and its role in the brain has been clarified recently. Studies have shown hepcidin plays an important role for in neuronal iron load and inflammation. This is of significance because neuronal iron load and inflammation are pathophysiological processes that have been highly linked to neurodegeneration. Moreover, the a...
[ 30 ] - Paeonol Protection Against Intrastriatal 6-Hydroxydopamine Rat Model of Parkinson\'s Disease
Introduction: Parkinsonchr('39')s disease (PD) presentations comprise frequent movement disorders in the elderly with various symptoms consisting of motor and non-motor complications. Paeonol is a phenolic chemical agent that has shown antioxidant and anti-inflammatory effects in different disorders and promising effects on metabotropic glutamate receptors (mGluR)- and GABAA-mediated neurotrans...
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