Keivan Majidzadeh Ardebili
Faculty of Medicine, Army University of Medical Sciences, Tehran, Iran
[ 1 ] - Aphylogenetic study on the NP gene of detected canine distemper virus in (2008-2011) Iran
BACKGROUND: Canine Distemper (CD) is a lethal systemicdisease affecting a wide variety of terrestrial carnivores.OBJECTIVES: This study was performed to survey epidemiologicaland molecular characteristics of the canine distemper virus(CDV) strains circulating in Iran. METHODS: In this study, 19CDV-suspected unvaccinated dogs from Northeast and center ofIran were analyzed for presence of CDV nuc...
[ 2 ] - Detection of Coxeilla brunetii in bulk tank milk samples from dairy bovine farms using nested-PCR in Qom, Iran, 2011
BACKGROUND: Q fever is a zoonotic disease caused byCoxiella burnetii, a species of bacteria that is distributedworldwide. In cattle, Coxiella burnetii infections are generallyasymptomatic but can also be associated with reproductivedisorders. OBJECTIVES: The aim of this study was to achievemolecular detection of Coxiella burnetii in dairy bovine milkfarms using Nested PCR in Qom province, Iran....
[ 3 ] - Echocardiographic assessment of myocardial infarction: comparison of a rat model in two strains
The purpose of this study was to induce myocardial infarction (MI) and compare the echocardiographic parameters and mortality ratio of Lewis inbred and Wistar outbred strain before and after the procedure to help choose the best one for MI studies. In this study MI was induced in 46 Lewis and 34 Wistar by occlusion of left anterior descending artery (LAD). Doppler, two-dimensional (2-D) and 2-D...
[ 4 ] - Detection of Arctic and European cluster of canine distemper virus in north and center of Iran
Canine distemper virus (CDV) creates a very contagious viral multi-systemic canine distemper (CD) disease that affects most species of Carnivora order. The virus is genetically heterogeneous, particularly in section of the hemagglutinin (H) gene. Sequence analysis of the H gene can be useful to investigate distinction of various lineages related to geographical distribution and CDV molecular ep...
[ 5 ] - طراحی واکنش زنجیره‌ای پلی‌مراز بهبودیافته جهت تشخیص مولکولی باکتری استرپتوکوکوس نیومونیا
زمینه و هدف: باکتری استرپتوکوکوس نیومونیا عامل مننژیت باکتریایی و یک عامل مهم مرگ و میر در کودکان و افراد سالخورده است. کنترل این بیماری نیز وابسته به تشخیص سریع باکتری می‌باشد. روش‌های تشخیص این باکتری شامل رنگ‌آمیزی گرم، کشت و تست‌های سرولوژیکی است. این روش‌ها وقت‌گیر و در اثر مصرف آنتی‌بیوتیک منجر به نتایج منفی کاذب می‌شوند. در حال حاضر، روش‌های مولکولی مانند PCR به‌صورت روزانه برای تشخیص عو...
[ 6 ] - مطالعه فراوانی آنتی بادی ضد ویروس دیستمپر در سگ‌های روستایی غیر واکسینه حاشیه جنوبی دریای خزر
زمینه مطالعه: طی سال‌های اخیر مرگ و میر‌های دسته جمعی در جمعیت فک‌های دریای خزر رخ داده و پاتوژن اصلی شناخته شده در این مرگ و میرها ویروس دیستمپر سگ‌ها (CDV) شناخته شد. علیرغم تکرار این پدیده و حضور تعداد بسیار زیاد لاشه فک‌های تلف شده در نواحی ساحلی کشورهای دریای خزر، اطلاعات زیادی در خصوص نقش اپیدمیولوژیک این حیوان در بقاء ویروس دیستمپر سگ‌ها در مناطق ساحلی وجود ندارد. هدف: هدف از انجام ...
[ 7 ] - Detection of Experimental Cryptosporidiosis in Neonatal Mice and Rats by Nested-PCR
Purpose: The purpose of this study is to model Cryptosporidiosis in laboratory animals. The parasites were inoculated into animalsand thenmultiplied. The process of proliferation was compared to controlCryptosporidiosis in humans. Materials and Methods: Twenty-five laboratory mice (4-7 days of age) and twenty-five laboratory rats (5 days of age) were assigned to the category I while the cat...
[ 8 ] - مقایسه نتایج دو روش ایمونوهیستوشیمی و Real-Time PCR در ارزیابی ژن HER-2 در بافت سرطانی پستان
سابقه و هدف: HER-2/neu یکی از نشانگرهای پیش آگهی مولکولی عمده در سرطان پستان بوده و با توجه به دستورالعمل های تصمیم گیری درمان، تکثیر این ژن در روند درمان بیماران مبتلا به سرطان پستان بسیار مهم می باشد. رایج ترین روش استفاده شده برای تشخیص تکثیر ژن HER-2/neu ایمونوهیستوشیمی (IHC) است. نتایج غیرقابل سنجش، عدم تکرارپذیری و زمان طولانی از اشکالات عمده این روش بوده که محققان را بر آن داشت...
[ 9 ] - The Interaction Between the Expression of Proliferative Biomarkers and Clinical Characteristics in Breast Cancer
Introduction: Proliferation of cancer cells and the potential of metastasis depend on the activity of different biomarkers such as proliferative ones. Proliferative biomarkers including ki-67, cyclin E1, cyclin D1, p27, and p21 were analyzed through immunohistochemistry (IHC) in previous studies. Methods: The current study aimed at investigating the utilizing role of RT-PCR in studying prolife...
[ 10 ] - The Applicability of the Gail Model in Iranian Population
Introduction: Gail model is one of the most important models for the evaluation of breast cancer risk between US white females. According to genetic diversity, there is a possibility of affecting the efficiency of the Gail model in risk assessment of breast cancer among Iranian populations. In this study, the Gail model efficiency in specifying the risk of breast cancer in Iranian population wa...
[ 11 ] - Multidisciplinary Cancer Investigation: A New Path to Delve into the Ocean of Cancer Sciences
On behalf of the editorial and executive board members, it is my great pleasure to present the Multidisciplinary Cancer Investigation Journal. The rapid growth of medical sciences has necessitated the development of platforms to distribute and publish the results of research projects, and declare new discoveries. Among all medical disciplines, cancer is the one that involves the largest number...
[ 12 ] - The Interaction Between the Expression of Proliferative Biomarkers and Clinical Characteristics in Breast Cancer
Introduction: Proliferation of cancer cells and the potential of metastasis depend on the activity of different biomarkers such as proliferative ones. Proliferative biomarkers including ki-67, cyclin E1, cyclin D1, p27, and p21 were analyzed through immunohistochemistry (IHC) in previous studies. Methods: The current study aimed at investigating the utilizing role of RT-PCR in studying prolife...
[ 13 ] - The Applicability of the Gail Model in Iranian Population
Introduction: Gail model is one of the most important models for the evaluation of breast cancer risk between US white females. According to genetic diversity, there is a possibility of affecting the efficiency of the Gail model in risk assessment of breast cancer among Iranian populations. In this study, the Gail model efficiency in specifying the risk of breast cancer in Iranian population wa...
[ 14 ] - Multidisciplinary Cancer Investigation: A New Path to Delve into the Ocean of Cancer Sciences
On behalf of the editorial and executive board members, it is my great pleasure to present the Multidisciplinary Cancer Investigation Journal. The rapid growth of medical sciences has necessitated the development of platforms to distribute and publish the results of research projects, and declare new discoveries. Among all medical disciplines, cancer is the one that involves the largest number...
[ 15 ] - مروری برمکانیسم‌های مولکولی وابسته به گیرنده Her-2 در مقاومت به تاموکسیفن در سرطان پستان
چکیده مقدمه: بروز مقاومت به تاموکسیفن در سلولهای سرطان پستان، برآیند عوامل محیطی، عوامل مربوط به میزبان و نیز مکانیسمهای مولکولی درون سلولی دخیل در رشد و تکثیر سلول است. مکانیسمهای مولکولی دخیل در بروز مقاومت به تاموکسیفن، متنوع میباشند. در این مقاله به نقش تغییر فعالیت گیرنده HER2 و در نتیجه تغییر فعالیت اجزای آبشار پیام رسانی وابسته به آن و در نهایت ژنهای متاثر از اجزای آبشار HER2در ب...
[ 16 ] - ارتباط پروتیین‌های لنگری A-کیناز با بقای بدون بیماری در سرطان پستان
Background: Researchers are always trying to find specific markers which express specifically in cancer. These specific markers help to diagnose and treat cancer without affecting normal tissues. Cancer-testis antigens are among the new promising biomarkers, especially for targeted therapy. These markers are specially expressed in testis. Various studies have been reported individual expression...
[ 17 ] - Functional Investigation of the Novel BRCA1variant (Glu1661Gly) byComputationalTools andYeastTranscription Activation Assay
Introduction: Mutations in the BRCA1 gene are major risk factors for breast and ovarian cancers. However, the relationship between some BRCA1 mutations and cancer risk remains largely unknown. Cancer risk predictions could be improved by evaluation of the impairment degree in the BRCA1 functions due to a specific mutation. This study aimed to assess the functional effect of a novel variant (Glu...
[ 18 ] - Functional Investigation of the Novel BRCA1variant (Glu1661Gly) byComputationalTools andYeastTranscription Activation Assay
Introduction: Mutations in the BRCA1 gene are major risk factors for breast and ovarian cancers. However, the relationship between some BRCA1 mutations and cancer risk remains largely unknown. Cancer risk predictions could be improved by evaluation of the impairment degree in the BRCA1 functions due to a specific mutation. This study aimed to assess the functional effect of a novel variant (Glu...
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