بختیاری, سالار
گروه بیوشیمی، دانشکده پزشکی، دانشگاه علوم پزشکی ایلام، ایلام، ایران
[ 1 ] - تعیین میزان بهبود لوکوموتور خودبخودی در موش های صحرایی با ضایعه نخاعی مزمن
مقدمه: ضایعه نخاعی(SCI) از جدی ترین بیماری های کلینیکی است که عوارض آن علاوه بر شخص بیمار، دامن گیر خانواده و جامعــه می شود. بعد از آسیب شدید نخاعی، آستروسیت های سیستم عصبی مرکزی با تبدیل به آستروسیت های واکنشی و ایجاد اسکار گلیال مانعی بزرگ برای بازسازی آکسون ها محسوب می شوند. در مطالعات مختلف، یک بهبود لوکوموتور نسبی خودبخودی در حیوانات دارای ضایعه با گذشت زمان و بدون هرگونه مداخله درمان...
[ 2 ] - بررسی اثرات رزیگلیتازون و اپیگالوکاتچین گالات بر بیان پروتئین PGC-1α در رده سلول‌های عضلانی C2C12 مقاوم به انسولین القا شده با پالمیتات
مقدمه: تغییر در سوخت و ساز لیپیدها یکی از سازوکارهای مهم برای درمان مقاومت به انسولین و در نتیجه دیابت نوع 2 است. از سوی دیگر، PGC-1α به عنوان یکی از تنظیم‌کنندههای کلیدی بیوژنز و عملکرد میتوکندری، از راه افزایش بتا- اکسیداسیون لیپیدها، نقش مهمی در بهبود حساسیت به انسولین ایفا میکند. در پژوهش حاضر، اثرات اپیگالوکاتچین گالات (EGCG)، به عنوان ترکیب ضدچاقی و افزاینده کاتابولیسم چربی، بر ...
[ 3 ] - Functional recovery assessment of spinal cord contusion model in male rats without therapeutic interventions
Introduction: Spinal cord injury (SCI) is one of the most serious clinical diseases, which not only affects the patient's physical and mental status, but its effects will be spread to family and community. After severe spinal cord injury, astrocytes of the central nervous system (CNS) become reactive astrocytes, and play the main role of glial scar formation. The scar is a major obstacle to r...
[ 4 ] - Investigating antimicrobial activity of hydroalcoholic extract and essential oil of Tymbra spicata against some pathogenic bacteria
Introduction: Thymbra spicata (T. spicata) is a conventional medicinal herb which is commonly used in the folklore medicine system of Iran. Aim of the study was to assess the antibacterial activity of the essential oil and hudroalcholic extract of the plant T. spicata on some important bacteria. Materials & methods: The essential oil and extract of T. spicata were obtained by hydrodistillation ...
[ 5 ] - اثرات عصاره هیدروالکلی گیاه تیمبرا بر باکتری‌های گرم مثبت و منفی بیماری‌زا
Background: Treatment of bacterial diseases by synthetic antibiotics leads to problems such as side effects in human and antibiotic resistance in microorganisms. Recently, plants have been given more attention in curing bacterial diseases. Since the use of Thymbra spicata is common in Iranian ancient medicine, this study tried to investigate the antibacterial effects of the extract of Thymbra...
[ 6 ] - بررسی فعالیت ضد باکتریایی عصاره هیدروالکلی خرزهره (Nerium oleander)
Background : Nerium oleander is used to cure several diseases in China and the Arabs, ancient medicine. This study tried to investigate the anti-bacterial activities of the hydroalcoholic extract of Nerium oleander which is native of Ilam province. Materials and Methods: Nerium oleander was collected from the Zagros mountains, Ilam province, Iran. After naming and identification, the plant ext...
[ 7 ] - Trehalose Neuroprotective Effects on the Substantia Nigra Dopaminergic Cells by Activating Autophagy and Non-canonical Nrf2 Pathways
Trehalose, as a natural disaccharide, is known as an autophagy inducer. The neuroprotectiveeffects of trehalose in the rat model of Parkinson′s disease were the aim of the present study.Parkinson′s disease model was induced by injecting 6-hydroxydopamine (6-OHDA) in thestriatum of male Wistar rats. Apomorphine-induced behavior and substantia nigra neuronalcounts were app...
[ 8 ] - Trehalose Neuroprotective Effects on the Substantia Nigra Dopaminergic Cells by Activating Autophagy and Non-canonical Nrf2 Pathways
Trehalose, as a natural disaccharide, is known as an autophagy inducer. The neuroprotectiveeffects of trehalose in the rat model of Parkinson′s disease were the aim of the present study.Parkinson′s disease model was induced by injecting 6-hydroxydopamine (6-OHDA) in thestriatum of male Wistar rats. Apomorphine-induced behavior and substantia nigra neuronalcounts were app...
[ 9 ] - Evaluating Chondroitin Sulfate and Dermatan Sulfate Expression in Glial Scar to Determine Appropriate Intervention Time in Rats
Introduction: The proteoglycans of the extracellular matrix increases in the glial scar during spinal cord injury and significantly affects the inhibition of axonal regeneration. Methods: The results of injury therapies are limited due to the lack of identifying a timely therapeutic intervention. The present study aimed to investigate the glial scar Chondroitin Sulfate (CS) and Dermatan Sulfa...
نویسندگان همکار