Amir Hossein Zarifkar
a. Department of Physiology, Shiraz University of Medical Sciences, Shiraz, Iran b. Department of Physiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences (AJUMS), Ahvaz, Iran
[ 1 ] - P62: Agmatine Protects Against Intracerebroventricular Streptozotocin-Induced Water Maze Memory Deficit, Hippocampal ApoptosisandAkt/GSK3β Signaling Disruption
Intracerebroventricular stereptozotocin (STZ) treatment has been described as a suitable model for sporadic Alzheimer’s disease (sAD). Centrally administered STZ decreases insulin and insulin receptors in the brain and interrupts PI3/Akt signaling pathway and GSK-3β. Additionally it raises Bax/Bcl-2 ratio and prompts hippocampal apoptosis. Agmatine, a polyamine derived from L-arginin...
نویسندگان همکار