Ali Hosseini-Sharifabad
Department of Pharmacology and Toxicology, Isfahan University of Medical Sciences, Isfahan, Iran.
[ 1 ] - Determination of Safety Margin for Hepatotoxic Effect of Mentha Longifolia Essential Oil in Rat
Background: Mentha longifolia is one of the aromatic medicinal plant belongs to Lamiaceae family. There are some active ingredients in the essential oil of M. longifolia, which potentially could impair the hepatic function. The aim of this study was to find the maximum dose of essential oil of M. longifolia (EOML) that does not show any hepatic deterioration. Methods: Adult Wistar rats fed d...
[ 2 ] - Effects of Maternal Alpha Methyldopa Administration on Memory of Rat Offspring during Growing Age
Background: Alpha Methyldopa (AMD) is a well-known treatment for the pregnancy induced hypertension and commonly used in several countries. Indeed the possible effect of AMD on the behavioral activities of offspring, whom are exposed during fetus period, has not been studied. The present study evaluated the possible effect of maternal administration of AMD on the rat offspring memory in the gro...
[ 3 ] - The Effect of Omega-lycotoxin on the Cognitive Impairment induced by Kainic acid in Rats
Background: Excitotoxicity is a common pathological process in neurodegenerative diseases associated with overactivity of N-methyl-D-aspartate (NMDA) and P/Q type voltage-gated calcium (Cav2.1) channels. Omega-lycotoxin-Gsp2671g is a therapeutic tool to modulate overactive Cav2.1 (P/Q type) channels. Omega-lycotoxin binds to Cav2.1 channels with high affinity and selectivity. This study aimed t...
نویسندگان همکار