Freshteh Ramezani

[ 1 ] - Maternal Betaine Homocysteine Methyltransferase Gene Polymorphism as a Risk Factor for Trisomy

Disorder in re-methylation process of homocysteine to methionine due to mutation in betaine homocysteine methyltransferase enzyme (BHMT) coding gene, leads to decrease in S-adenosyl methionine (SAM) synthesis which takes part in DNA methylation as a methyl donor. As a result, it can promote hypo-methylation of DNA, chromosome instability, and chromosome missegregation, which in turn is one of t...