مهبودی, فریدون
گروه بیوتکنولوژی پزشکی، انستیتو پاستور ایران
[ 1 ] - بهینهسازی تولید فعالکننده پلاسمینوژن بافتی نوترکیب در انگل لیشمانیای غیر بیماریزا با طراحی دو سازۀ ژنی
Background: Recombinant tissue plasminogen activator (rt-PA) is one of the most important thrombolytic agentsused in patients with vascular occlusions such as acute ischemic stroke or myocardial infarction. A variety of recombinant protein expression systems have been developed for heterologous gene expression in prokaryotic and eukaryotic hosts. In recent years, Leishmania tarentolae (L. tare...
[ 2 ] - Woodchuck Hepatitis Virus Post-Transcriptional Regulation Element (WPRE) Promotes Anti-CD19 BiTE Expression in Expi293 Cells
Background: Bispecific antibodies represent an important class of mAbs, with great therapeutic potentials due to their ability to target simultaneously two distinct epitopes. The generation of functional bispecific antibodies with the highest possible yields is particularly critical for the production of these compounds on industrial scales. Anti- CD3 × CD19 bsAb is a bispecific T-cell engager ...
نویسندگان همکار