احمدی, رحیم
گروه فیزیولوژی، دانشکده علوم پایه، واحد همدان، دانشگاه آزاد اسلامی، همدان، ایران
[ 1 ] - The Effect of Progesterone on the Viability of MCF-7 Cell Line and Evaluation of Expression of P53, BAX and BCL-2 Genes
Background and Objectives: Researches have shown that progesterone influences the viability of breast cancer cells. The purpose of this study was to investigate the effect of progesterone on the viability of MCF-7 cell line and evaluation of Expression level of P53, Bax, and Bcl-2 Genes. Methods: In this laboratory-experimental study, MCF-7 cells were purchased from Pasture institute and div...
[ 2 ] - The Cytotoxic Effects of Testosterone on Gastric Cancer Cell Line (AGS) and Evaluation of Caspase-3, -8, and -9 Activity
Background and Objectives: Various studies have shown that sex steroids affect cancer cells at cellular and molecular level. In this study, the anti-proliferation effects of testosterone, was investigated on gastric cancer cell line (AGS) and activity level of caspase-3, -8 and -9, was evaluated. Methods: In this laboratory experimental study, AGS cell line, were randomly divided into contro...
[ 3 ] - بررسی اثرات عصاره هیدروالکلی جلبک Sargassum ciliforium بر رده سلولی سرطان کولون HT-29 و ارزیابی بیان ژن های P53 و APCبا روش Real time PCR
سرطان روده بزرگ سومین سرطان شایع در جهان است. با توجه به افزایش بروز سرطان استفاده از مولکول های جدید شیمی درمانی مورد نیاز می باشد. بسیاری از مطالعات و تحقیقات نشان داده است که سرطان روده می تواند از طریق محصولات دریایی طبیعی که دارای مقادیر بسیاری از مواد فعال بیولوژیکی با ساختارهای شیمیایی و فعالیت های دارویی جدید هستند درمان شود. هدف از این مطالعه بررسی اثرات عصاره هیدروالکلی جلبک Sargassum...
[ 4 ] - Evaluation the effects of diclofenac and oxaliplatin on the expression of caspase8 and caspase9 genes in Colorectal Cancer cell line(SW480)
Background and Aim: Induction of apoptosis is one of the main goals in the production of anticancer drugs. Recently, the evaluation of the association between nonsteroidal anti-inflammatory drugs (NSAIDs) and apoptosis in cancer cells has been promising. Caspase8, caspase9. Methods: In this experimental-laboratory study, sw480 colorectal cancer cells were treated with different concentrations o...
[ 5 ] - EVALUATION OF THE EFFECTS OF IBUPROFEN CYTOTOXIC DOSE ON EXPRESSION LEVEL OF EXTRACELLULAR MATRIX DEGRADING MMP-9 AND ANTI-METASTASIS NM23 GENES IN CERVICAL CANCER CELLS
Background & Aim: Although studies have shown that ibuprofen has anticancer effects on many cancer cells, the mechanism of the ibuprofen anticancer effect in cancer cells is not still well understood. The aim of this study was to investigate the effect of cytotoxic concentration of ibuprofen on the expression level of MMP-9 and NM23 genes in cervical cancer cells. Materials & Methods: During t...
[ 6 ] - The effects of umbilical cord Wharton jelly derived mesenchymal stem cells injection on diabetic wound healing in male rats
Background: The number of patients suffering from diabetic ulcers has been increased in recent years and the current therapies have faced failure. This study aimed to investigate the effects of Wharton’s jelly stem cells (WJMSCs) on the diabetic wound in an animal mode. Methods: During this laboratory experimental study carried out in Skin and Stem Cells Research Center from March 2021 to Nove...
[ 7 ] - Evaluation of the effect of an intradermal injection of Wharton\'s jelly-derived mesenchymal stem cells in diabetic wound healing in animal model
Background: The application of mesenchymal stem cells in the healing of chronic wounds is one of the most challenging issues in cell therapy. The present study investigated the efficacy of intradermal injection of umbilical cord Wharton's Jelly-derived mesenchymal stem cells in diabetic wound healing using ultrasound imaging in an animal model. Methods: During this experimental laboratory stud...
[ 8 ] - Skin wound healing following the spray of human abdominal adipose tissue-derived mesenchymal stem cells in diabetic male rat
Introduction: Diabetes is rising worldwide and impaired wound healing is one of its major complications. This study aimed to determine the effects of adipose-derived mesenchymal stem cells (MSCs) on wound healing in diabetic rats. Materials and Methods: In this experimental study, abdominal adipose tissue was obtained from 10 patients who underwent an abdominoplasty. MSCs were isolated from adi...
[ 9 ] - The Effect of Transplantation of Collagen Hydrogel with Adipose-Derived Mesenchymal Stem Cells on Burn Wound Healing in Rats
Background: Cell therapy is one of the most challenging methods in the healing of burn wounds in the world. The present study aimed to determine the effect of collagen hydrogel with adipose-derived mesenchymal stem cells on burn wound healing in an animal model. Materials and Methods: The present study was experimentally performed on 24 Wistar rats. Burn wounds were created on the skin of rats...
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