Sadaf Nezamoleslami
Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran | Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran
[ 1 ] - The protective effects of curcumin and curmumin nanomicelle against cirrhotic cardiomyopathy in bile duct-ligated rats
Objective(s): Cirrhotic cardiomyopathy refers to cardiac muscle dysfunction caused by liver cirrhosis. Seemingly, free radicals and inflammatory factors play a critical role in the pathophysiology of cardiomyopathy. Curcumin has the anti-inflammatory, antioxidant, and anticancer properties . However, the therapeutic indications of this compound are limited due to its low absorption, rapid metab...
[ 2 ] - Current Models for Predicting Drug-induced Cholestasis: The Role of Hepatobiliary Transport System
Drug-induced cholestasis is the main type of liver disorder accompanied by high morbidity and mortality. Evidence for the role of hepatobiliary pumps in the cholestasis patho-mechanism is constantly increasing. Recognition of the interactions of chemical agents with these transporters at the initial phases of drug discovery can help develop new drug candidates with low cholestasis potential. Th...
[ 3 ] - Current Models for Predicting Drug-induced Cholestasis: The Role of Hepatobiliary Transport System
Drug-induced cholestasis is the main type of liver disorder accompanied by high morbidity and mortality. Evidence for the role of hepatobiliary pumps in the cholestasis patho-mechanism is constantly increasing. Recognition of the interactions of chemical agents with these transporters at the initial phases of drug discovery can help develop new drug candidates with low cholestasis potential. Th...
نویسندگان همکار