محمد درخشان
دانشیار گروه باکتری شناسی و ویروس شناسی بالینی بیمارستان آموزشی قائم. دانشکده پزشکی و مرکز تحقیقات مقاومتهای میکروبی. دانشگاه
[ 1 ] - عفونت ویروسی و سندرم ضعف مزمن (CFS)
مقدمه بسیاری از مطالعات و بررسیها نشان دادهاند که ویروسها میتوانند پس از ورود به سلول میزبان با میتوکندری تعامل کرده و عملکرد آن را مختل گردانند به ویژه اینکه برخی تحقیقات مشخص کردهاند که این اثرات میتواند تغییراتی در ساختمان میتوکندری و همچنین تغییراتی در مسیر تولید انرژی سلولی در زنجیره انتقال الکترون ایجاد نماید که این امرگاها باعث کاهش شدید انرژی سلولی در انتهای فرایند انتقال الکترون...
[ 2 ] - ارزیابی تاثیر ضدباکتریایی ژل بهداشت دست در غلظتهای مختلف باکتری
چکیده: مقدمه: برای جلوگیری ازعفونت‌های بیمارستانی رعایت بهداشت دست اهمیت دارد، یکی از روش‌های از بین بردن سریع میکروارگانیسم‌ها استفاده از ژل بهداشت دست بر پایه الکل است. هدف از این آزمایش بررسی اثر بخشی ژل بهداشت دست در غلظتهای مختلف باکتری است. روش‌کار:برای این مطالعه علوم پایه از ژل بهداشت دست مرسوم در بیمارستان های مشهد استفاده شد. ابتدا سوسپانسیونی از باکتری Staphylococcusaureusبا کد...
[ 3 ] - Potential of polymeric particles as future vaccine delivery systems/adjuvants for parenteral and non-parenteral immunization against tuberculosis: A systematic review
Objective(s): Production of effective tuberculosis (TB) vaccine is necessity. However, the development of new subunit vaccines is faced with concerns about their weak immunogenicity. To overcome such problems, polymers-based vaccine delivery systems have been proposed to be used via various routes. The purpose of this study was to determine the potential of polymeric particles as future vaccine...
[ 4 ] - Fasting and apoptosis: a mini review
Fasting, that is usually described as abstinence from all food and drink for a period of time, has been experienced for ages. Health, protest, religious expressions of devotion and purification are the most important reasons for fasting. Many changes occur in the body during fasting including metabolic, mineral, hormonal, immunological and psychological. Its use as one of the oldest therapies a...
[ 5 ] - Designing and Construction of a Cloning Vector Encoding mtb32C and mpt51 Fragments of Mycobacterium Tuberculosis as a DNA Vaccine Candidate
Background & objective: Tuberculosis (TB) remains a major cause of death around the world. Bacillus Calmette Guérin (BCG) is the only vaccine used in TB prevention that has a protective effect in children, but its effectiveness declines in adults. Design and development of new vaccines is the most effective way against TB. The aim of this study was to design and construc...
[ 6 ] - Formulation and optimization of a new cationic lipid-modified PLGA nanoparticle as delivery system for Mycobacterium tuberculosis HspX/EsxS fusion protein: An experimental design
Polymeric particles and liposomes are efficient tools to overcome the low immunogenicity of subunit vaccines. The aim of the present study was formulation and optimization of a new cationic lipid-modified PLGA nanoparticles (NPs) as a delivery system for Mycobacterium tuberculosis HspX/EsxS fusion protein. The cationic lipid-modified PLGA NPs containing HspX/EsxS fusion protein were prepared us...
[ 7 ] - Formulation and optimization of a new cationic lipid-modified PLGA nanoparticle as delivery system for Mycobacterium tuberculosis HspX/EsxS fusion protein: An experimental design
Polymeric particles and liposomes are efficient tools to overcome the low immunogenicity of subunit vaccines. The aim of the present study was formulation and optimization of a new cationic lipid-modified PLGA nanoparticles (NPs) as a delivery system for Mycobacterium tuberculosis HspX/EsxS fusion protein. The cationic lipid-modified PLGA NPs containing HspX/EsxS fusion protein were prepared us...
[ 8 ] - Enhancing immunogenicity of novel multistage subunit vaccine of Mycobacterium tuberculosis using PLGA:DDA hybrid nanoparticles and MPLA : subcutaneous administration
Objective(s): A new strategy in recent studies is using effective tuberculosis (TB) subunit vaccines combined with appropriate carriers and adjuvants which have shown promising results in preclinical and clinical studies. The aim of the present study was to evaluate the PLGA:DDA hybrid nanoparticles (NPs) for subcutaneous delivery of a novel multistage subunit vaccine ...
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