محمود اله دادی سلمانی
استادیار فیزیولوژی، دانشکده زیست‌شناسی، دانشگاه دامغان، دامغان، ایران
[ 1 ] - بررسی اثر کیندلینگ پنتیلین‌تترازول و غیرفعالسازی هیپوتالاموس جانبی بر روند کیندلینگ و جمعیت نورونی هیپوکامپ
زمینه و هدف:صرع یک اختلال عصبی ناشی از تغییرات سیناپسی است که منجر به افزایش تحریکپذیری و تغییرات ساختاری بافت مغزی میگردد. کیندلینگ یک مدل حیوانی صرع است که طی تحریک های مکرر الکتریکی یا شیمیایی زیرآستانهای منجر به تغییرات سیناپسی و مداری در مغز می شود. هیپوتالاموس جانبی به عنوان کانون اصلی نورون های اورکسینرژیک در خواب و بیداری و نیز تحریکپذیری مغزی دخیل است و گیرنده های زیادی در هیپوکامپ...
[ 2 ] - Effect of eugenol on lithium-pilocarpine model of epilepsy: behavioral, histological, and molecular changes
Objective(s): Epilepsy establishment gives rise to biochemical and morphological changes in the hippocampus. Oxidative stress, morphological changes, and mossy fiber sprouting (MFS) in the hippocampus underpin the epilepsy establishment. Eugenol is the main component of the essential oil extracted from cloves with the potential to modulate neuronal excitability. Therefore, we investigated the e...
[ 3 ] - Acute stress does not affect the impairing effect of chronic stress on memory retrieval
Objective(s): Due to the prevalence and pervasiveness of stress in modern life and exposure to both chronic and acute stresses, it is not clear whether prior exposure to chronic stress can influence the impairing effects of acute stress on memory retrieval. This issue was tested in this study. Materials and Methods: Adult male Wistar rats were randomly assigned to the following groups: control,...
[ 4 ] - Stress during first pregnancy increases seizure threshold in adult male offspring
Objective(s): Stress induces many homeostatic aberrations which are followed by lifelong allostatic responses. Epilepsy is developed or influenced by different environmental factors, i.e. prenatal stress which makes many contradictory developmental changes in seizure threshold and intensity. We investigated the potential seizure response of the rat offspring to prenatal stress; the stres...
[ 5 ] - Role of Oxidative Stress in Ethanol-induced Neurotoxicity in the Developing Cerebellum
Objective(s) The purpose of this study was to investigate the role of oxidative stress in Purkinje cell neurotoxicity ofethanol-treated rat. Materials and Methods Male rat pups 4-day-old was used in this study. Ethanol was administered to rat pups at a dose of 6 g/kg from postnatal days (PDs) 4 to 5. Pups were killed 90 min after the second alcohol treatment on PD 5 by decapitation and the ...
[ 6 ] - Effect of Cannabinoid Receptor Agonist WIN55, 212-2 on the Anxiety Induced by PTSD in Male Rats
Introduction: Posttraumatic stress disorder is a severe anxiety disorder caused by exposure to traumatic events. The aim of this study was to induce PTSD in rats and examine the effect of WIN55-212-2, a cannabinoid receptor agonist, on anxiety. Methods: SPS&S model was used to induce PTSD in 56 male Wistar rats. Rats were restrained for 2 h, immediately followed by forced swimming for 20 mi...
[ 7 ] - Chronic heterogeneous sequential stress increases formalin-induced nociceptive
Abstract Introduction: Chronic heterogeneous stress may be better for evaluation of the effect of chronic stress situations on the nociceptive behaviour. The present study investigated the effects of chronic heterogeneous sequential stress on thermal-induced nociception and formalin induced pain behavior in rats. Methods: In the present study, adult rats (220-300 g) were used. Animals were ...
[ 8 ] - Altered expression of orexin 1 and endocannabinoid 1 receptors of the hippocampus in three pentylenetetrazol, pilocarpine and kainate seizure models
Introduction: Seizure is synchronous and abnormal brain neuronal activity that leads to activation of different receptors capable of enhancing or suppressing seizure activity such as orexin receptor 1 (OXR1) and/or endocannabinoid receptor 1(CBR1). The time of activation for the receptors may influence seizure control. Therefore, this study aimed to investigate the latency for and the change of...
[ 9 ] - Lateral Hypothalamus Corticotropin Releasing Hormone Receptor-1 Inhibition Modulates Stress- Induced Anxiety Behavior
Stress is a reaction to unwanted events disturbing body homeostasis which influences its pathways and target areas. Stress affects the brain through the lateral hypothalamic area (LHA) orexinergic system that mediates the effect of corticotropin-releasing hormone (CRH) through CRH receptor type 1 (CRHr1). Therefore, this study explores the outcome of stress exposure on anxiety development and t...
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