Esmaeal Tamaddonfard
Division of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
[ 1 ] - The effects of crocin, insulin and their co-administration on the heart function and pathology in streptozotocin-induced diabetic rats
Objective: Crocinisa saffron constituent with a potent anti-oxidant activity. The present study investigated the effects of crocin and insulin treatments (alone or in combination) on cardiac function and pathology in diabetic rats. Materials and Methods: Diabetes was induced by intraperitoneal (i.p.) injection of streptozotocin (STZ, 50 mg/kg). Thereafter, crocin (5, 10 and 20 mg/kg, i.p.), sub...
[ 2 ] - Effects of crocin and safranal, saffron constituents, on the formalin-induced orofacial pain in rats
Objective: Crocin and safranal are the main components of saffron, and have many biological functions such as anti-inflammatory and antioxidant activities. In the present study, we investigated the effects of crocin, safranal, morphine, diclofenac and naloxone in combined and separately on formalin-induced orofacial pain in rats. Materials and Methods: Subcutaneous injection of a diluted formal...
[ 3 ] - Effects of crocin and zinc chloride on blood levels of zinc and metabolic and oxidative parameters in streptozotocin-induced diabetic rats
Objectives:Crocin is one of constituents of saffron and has antioxidant property. Zinc chloride is one of the common compounds of zinc with antioxidant activity. The present study was aimed to investigate separate and combined treatment effects of crocin and zinc chloride on blood levels of zinc and metabolic and oxidative parameters in diabetic rats. Materials and Methods:Diabetes was induced ...
[ 4 ] - Effects of intra-fourth ventricle injection of crocin on capsaicin-induced orofacial pain in rats
Objectives: Crocin, a constituent of saffron and yellow gardenia, possesses anti-nociceptive effects. In the present study, we investigated the effects of intra-fourth ventricle injection of crocin in a rat model of orofacial pain. The contribution of opioid system was assessed using intra-fourth ventricle injection of naloxone, an opioid receptor antagonist. Materials and Methods: A guide cann...
[ 5 ] - Effect of curcumin, the active constituent of turmeric, on penicillin-induced epileptiform activity in rats
Objective: Curcumin is a major constituent of turmeric and has many biological functions such as anticancer and anti-inflammatory effects. The present study was conducted to investigate the effects of curcumin and diazepam in separate and combined treatments on penicillin-induced seizures in rats. Materials and Methods: In urethane-anesthetized rats, epileptiform activity was induced by intrac...
[ 6 ] - Effects of histidine and vitamin C on isoproterenol-induced acute myocardial infarction in rats
In the present study, we investigated the effects of histidine and vitamin C (alone or in combination) treatments against isoproterenol (a β-adrenergic receptor agonist)-induced acute myocardial infarction in rats. We used propranolol (a β-adrenergic receptor blocker) to compare the results. Rats were given intraperitoneal injections of histidine (40 mg kg-1) and vitamin C (40 mg kg<...
[ 7 ] - Role of opioid system in verapamil-induced antinociception in a rat model of orofacial pain
Calcium, through its various channels involves in local, spinal and supra-spinal transmission of pain. In the present study, we investigated the separate and combined treatment effects of verapamil (a calcium channel blocker), morphine (an opioid agonist) and naloxone (an opioid antagonist) on pain in the orofacial region of rats. Orofacial pain was induced by subcutaneous (SC) injection of for...
[ 8 ] - اثر تزریق داخل هیپوکامپی هیستامین و تیوپرامید بر درد تونیک ناحیه دهانی - صورتی در موش صحرایی
Background & Aims : Brain histamine, through H3 receptor, has an important role in central perception of pain. The present study investigated the effects of intra-hippocampal microinjection of histamine and thioperamide (a histamine H3 antagonist) on tonic pain in orofacial region of rats. Materials & Methods: In 72 male Wistar rats two guide cannulae were implanted into the dorsal hippocam...