Androstenedione is a steroid hormone and the major precursor to testosterone. It is available without prescription and taken with the expectation that it will be converted to testosterone endogenously and increase strength and athletic performance. The metabolism of orally administered testosterone has not been well studied. We randomly assigned 37 healthy men to receive 0, 100, or 300 mg oral ...

We report a phase diagram mapping for solid hydrogen based on several thousands of Raman spectroscopic data points obtained at simultaneous high-pressure and -temperature (PT) experiments. Information about behavior in the range 300 K up to melting line 0--300 GPa has remained almost unknown date; therefore, revealing it is very desirable. A network analysis isothermal isobaric dependencies var...

Objective: To assess polycythaemia vera (PV)-related retinal microvascular morphological changes using optical coherence tomography angiography (OCTA). Material and Methods: In this cross-sectional case-control study, 30 PV patients (Group 1) healthy individuals 2) underwent a comprehensive ophthalmological examination, followed by OCTA acquisition in Angio Retina mode (6x6 mm). Macular superfi...

(11:21); hence from the very nature of creation Browne may conclude: "All things began in order, so shall they end, and so shall they begin again; according to the ordainer of order and mystical mathematics of the City of Heaven." Browne could not know in 1658 that he would live for another 24 years. As though The Garden of Cyrus is actually his final work he joins it, like a snake swallowing i...

7-O-Benzoylpyripyropene A (7-O-BzP), a semi-synthetic analog of pyripyropene, was investigated for its reversing effect on multidrug-resistant (MDR) tumor cells. 7-O-BzP (6.25 microg/ml) completely reversed resistance against vincristine and adriamycin in vincristine-resistant KB cells (VJ-300) and adriamycin-resistant P388 cells (P388/ADR), respectively. 7-O-BzP alone had no effect on the grow...

We describe different neuropharmacological effects of Verbena officinalis crude extract (Vo.Cr). Pentylenetetrazole (PTZ)-induced seizures, elevated plus maze, light-dark box (LDB), open field and thiopental-induced sleeping test models were employed to evaluate Vo.Cr actions in mice. Vo.Cr dose-dependently (100-500 mg/Kg) delayed onset time of myoclonic jerks and tonic-clonic seizures, while d...

Two hundred and forty avian broilers were equally divided into four groups, and raised with a corn-soybean basal diet or the same diet supplemented with 300, 600, 900 mg/kg NiCl2 for 42 days. Numbers or percentages of apoptotic splenocytes by flow cytometry (FCM) and TUNEL were higher (p < 0.05 or p < 0.01) in the 300, 600 and 900 mg/kg groups than those in the control group. Results measured b...