سابقه و هدف: نشان داده شده است که التهاب حاد منجر به تغییر در گیرنده های عروقی آدرنرژیک که واسطه عمل سیستم سمپاتیک در تنظیم جریان خون مفصلی می باشند، از اکثریت آلفا-2 به تساوی آلفا-1 و آلفا-2 می گردد. در تحقیق حاضر اثر انقباضی سیستم عصبی سمپاتیک بر عروق مفصلی و تغییرات احتمالی در پروفیل گیرنده های آلفا آدرنرژیک در اثر التهاب مزمن مورد بررسی قرار گرفته است. مواد و روش ها: برای این منظور در 21 خر...

                    Aim and Background:   Shivering is a common post anesthesia complication. Intravenous Methods and Materials:   In a RCT, 60 adult patients in ASA class 1 & 2 scheduled for   c . At the end of the anesthesia, the patients’ shivering was evaluated in the Findings:   There was no difference at decrease of SpO2 &...

This study was conducted to evaluate effect of clonidine as a premedication on endoscopic sinus surgery bleeding.Methods and Materials: during a randomized double blind clinical trial we compared two groups of patients who scheduled for endoscopic sinus surgery for polypectomy and etmoidectomy. 216 patients randomly assigned in two groups.In first group 2 hours befor surgery a 0.2mg tablet of c...

    Background & Aim: Clonidine, an alpha 2 agonist, attenuates sympathetic responses during general anesthesia and improves the intra-operative hemodynamic stability. In this randomized double blinded clinical trial study, we report the effects of 300µg oral clonidine premedication(n=22) or placebo(n=22) on hemodynamic alteration during gynecologic laparoscopic surgery, under general anesthesi...

AbstractObjectives: This project was conducted to compare two programs of treatment, the rapid (naltrexone/ clonidine) and the conventional (clonidine) detoxification. Method: 54 opioid dependent patients referred to the clinic of Iran Educational Psychiatric Center participated in the study they were randomly placed in two groups. 28 patients in group A (naltrexone/ clonidine) and 26 patients ...

Background and Aim: Shivering is an unpleasant complication of General Anesthesia which is seen in 40% of cases. Shivering is a serious complication that increases oxygen consumption to several times and results in increased ventilation, cardiac output, myocardial ischemia, intraocular & intracerebral pressure and intensity of postoperative pain. Preventing this unwanted complication is necessa...

Background: Blood loss in spine surgery is an important issue, even though it has been understudied compared to hip and knee arthroplasty surgery. In this study we have evaluated the effect of oral clonidine as premedication on blood loss in lumbar spine fusion surgery under propofol and remifentanil anesthesia.Materials and Methods: In this prospective double-blinded randomized clinical trial,...

Background & Aims: Pain following surgery can cause physical, cognitive and emotional distress. Clonidine is an alpha-2 agonist that has recently been used to reduce anxiety and pain and it may help prevent postoperative discectomy complications. Our aim was to determine the efficacy and safety of α-2 adrenergic agonists for reducing pain and complications in adults undergoing spine surge...

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Introduction & Objective: ECT is an inevitable therapy for many of psychiatric patients. During ECT severe hemodynamic changes occur which may cause dangerous cardiovascular complications especially in elderly patients with cardiac disease and may lead to arrhythmia,ischemia and myocardial infarction. The purpose of this study was to show the effect of clonidin and propranolol on the preventi...