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We have developed a new helper-dependent (HD) adenoviral vector FTC that contains 3 cis-acting sequences as stuffer DNA: a human fragment of alphoid repeat DNA, matrix-attachment regions (MARs), and the hepatocyte control region enhancer. To determine the most robust human coagulation factor IX (hFIX) expression cassette in an adenovirus, we first tested different hFIX expression sequences with...
Circulating serum 25-hydroxyvitamin D (25(OH)D) levels reflect the net contribution of food and supplement intake as well as skin production through sun exposure, and are widely accepted as the standard to assess for individual adequacy or insufficiency. Recent work has demonstrated the pleiotropic effects of vitamin D on cellular differentiation, proliferation, apoptosis and angiogenesis. Vita...
گونه های آویشن ( نعناعیان ) عمدتا استفاده دارویی دارند . چون رده بندی بر اساس صفات مورفولوژیکی، بیشتر تحت تاثیر شرایط محیطی قرار می گیرد در نتیجه رده بندی گونه های این جنس بر اساس صفات مورفولوژیکی قابل اطمینان نمی باشد. در این مطالعه هدف بررسی روابط فیلوژنتیکی و رده بندی بین گونه هایی از thymus از استان آذربایجان شرقی ایران به نام هایt. pubescens وt. trautvetteri وt. kotschyanus و t.daenensisدر...
The aim of the study reporfed here was to determine if bifurcated needles or multiple puncture cylinders would prove suitable for administration of measles vaccines. Children 9 to 11 months old in S#o Paula, Brazil, were assigned to receive either BikenCam 70 (5 000 TCl0,dO.S ml) or Edmonsfon-Zagreb (7 000 TCID,,IO.5 ml) measles vaccine intradermally with a bifurcated needle or a multiple punct...
A rapid, sensitive and selective liquid chromatography-tandem mass spectrometry was developed to determine two epimeric furofuran lignans (sesamin and asarinin) simultaneously from Asarum heterotropoides extract in rat plasma. Simple protein precipitation with acetonitrile was performed to extract analytes by using alantolactone as an internal standard. Chromatographic separation was achieved u...
The infectious dose of a virus pool of original US PEDV strain PC22A was determined in 4-day-old, cesarean-derived, colostrum-deprived (CDCD) piglets. The median pig diarrhea dose (PDD50) of the virus pool was determined as 7.35 log10 PDD50/mL, similar to the cell culture infectious titer, 7.75 log10 plaque-forming units (PFU)/mL. 100 PDD50 caused watery diarrhea in all conventional suckling pi...
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