The liver is one of the organs involved in the multiorgan failure that occurs in sickle cell disease, the pathophysiology of liver disease in this condition is complex because of the interrelated multifactorial causes. Liver dysfunction was assessed in both paediatric and adult sickle cell disease patients in the steady state. The transaminases and alkaline phosphatase were analysed by automati...

The search for new producers of α-L-rhamnosidases and the study their properties are constantly carried out, which makes it possible to identify enzymes with unique properties. Thus, marine species microorganisms can radically differ in habitat conditions from terrestrial ones. Previously, we have isolated a number representatives Black Sea microbiota. However, results these studies did not all...

Background: IKAROS, encoded by Ikaros Family Zinc Finger 1 (IKZF1), is a zinc finger transcription factor and critical regulator of hematopoiesis. We previously found that human epidermis expressed IKZF1. In addition, we generated K5-Ikzf1-EGFP transgenic mice (Ikzf1 Tg) introducing the IKZF1 isoform into cells expressing keratin 5 which developed dermatitis also patchy alopecia. A previous in ...

Previous studies of follicular lymphoma (FL) patients treated heterogeneously have suggested that decreased numbers of regulatory T cells correlates with improved survival. We studied advancedstage FL patients from a single institution phase 2 trial. All patients were treated uniformly with multiagent chemotherapy and radiation. Tissue microarrays were constructed using diagnostic biopsies avai...

On September 18, 2022, an alert by ceCube indicated that a ~170TeV neutrino arrived in directional coincidence with the blazar TXS 0506+056. This event adds to two previous ones: from its direction on 22, 2017, and 3sigma signature of dozen neutrinos 2014/2015. deBruijn 2020 showed these emission episodes could be due supermassive binary black hole (SMBBH) where jet precession close final coale...

Abstract Aim Description of the adoption process, first experiences and pitfalls with a surgical robot for hernia surgery in private practice. Material & Methods consecutive experience 30 cases including redo inguinal hernias previous preperitoneal mesh placemen, prostate incional hernias. Results There were no complications. The usage pain medication was significantly lower comparison to “...