Carbon monoxide, which is generated in mammals during the degradation of heme by the enzyme heme oxygenase, is an important signaling mediator. Transition metal carbonyls have been recently shown to function as carbon monoxide-releasing molecules (CO-RMs) and to elicit distinct pharmacological activities in biological systems. In the present study, we report that a water-soluble form of CO-RM p...

OBJECTIVE Carbon monoxide-releasing molecules (CORMs) represent a pharmacological alternative to CO gas inhalation. Here, we questioned whether CORM-3, a well-characterized water-soluble CORM, could prevent and reverse pulmonary hypertension (PH) in chronically hypoxic mice and in smooth muscle promoter 22 serotonin transporter mice overexpressing the serotonin transporter in smooth muscle cell...

Carbon monoxide (CO) is well-known as toxic gas and intrinsic signaling molecule such as neurotransmitter and blood vessel relaxant. Recently, it has been reported that low concentration of CO exerts therapeutic actions under various pathological conditions including liver failure, heart failure, gastric cancer, and cardiac arrest. However, little has been known about the effect of CO in neurod...

In recent years, it has been discovered that septic patients display coagulation abnormalities. Platelets play a major role in the coagulation system. Studies have confirmed that carbon monoxide (CO) has important cytoprotective and anti-inflammatory function. However, whether CO could alter abnormal activation of platelets and coagulation and thereby reduce the incidence of mortality during se...

in order to investigate the effects of corm tunic, corm weight and drought stress on saffron (crocus sativus l.), an experiment was conducted at the greenhouse of ferdowsi university of mashhad, iran. treatment were combination of four corm weights range (2-4, 4-6, 6-8 and 8-10 g), two levels of water availability (100% field capacity and drought) and two levels of corm tunic (natural corm with...

Carbon monoxide (CO) releasing molecules (CO-RMs) have been shown to inhibit growth of commensal Escherichia coli (E. coli). In the present study we examined the effect of CORM-2 on uropathogenic E. coli (UPEC) that produces extended-spectrum β-lactamase (ESBL). Viability experiments showed that CORM-2 inhibited the growth of several different ESBL-producing UPEC isolates and that 500 μM CORM-2...

This research was conducted in 2007 and 2008 cropping seasons in the experimental field of Shahid Salemi, Ahvaz, south west of Iran. In each year, the study consisted of a split split-plot experiment, using Randomized Complete Block Design (RCBD) with three replications. Four irrigation levels including irrigationoff at the 8 leaf, the 12 leaf and the tasseling stages and optimum irrigation wer...