OBJECTIVES The aims of this study were to develop a population pharmacokinetic model of vancomycin in adult patients, to use this model to develop dosage guidelines targeting vancomycin trough concentrations of 10-15 mg/L and to evaluate the performance of these new guidelines. METHODS All data analyses were performed using NONMEM. A population pharmacokinetic model was first developed from v...

We followed the "abbreviated precision protocol" of the National Committee for Clinical Laboratory Standards for the evaluation of precision, accuracy, and carryover in analysis for urea nitrogen with the multilayer film analysis system ("Ektachem"). We analyzed 456 clinical samples with this instrument, by the manual urease/glucose dehydrogenase method, and with the Beckman System I GLU/BUN An...

Some cultivars of grapevine have very compact cluster which adversely affect its quality and marketability. ‘Yaghouti’ is a commercial early table grape cultivar that has very compact clusters. The present study was conducted to assess the effects of mechanical and chemical thinning as well as GA3 application on cluster morphology and berry size of grapevine cv. ‘Yaghouti’. Treatments were chem...

BACKGROUND AND THE PURPOSE OF THE STUDY In Parkinson›s disease (PD) prolong use of L-DOPA causes some motor disorders such as wearing-off and L-DOPA induced dyskinesia (LID). In this investigation the effect of 8-OHDAPT, as a 5-HT(1A) agonist on anti-cataleptic effect of L-DOPA in 6-hydroxydopamine (6-OHDA) lesioned male Wistar rats was investigated. METHODS Catalepsy was induced by unilatera...

The abundant presence of fluoride (F-) in surface water bodies is an environmental concern because its effects on human health; medical reports confirmed that intake above 1.5 mg/L leads to many health complications, including but not limited weak bones and enamel fluorosis. Thus, the World Health Organisation (WHO) defines 1.20 as maximum permissible F- concentration drinking water. electrocoa...

Steeping of Kenop flower (Gomphrena globosa L.) is widely used as a health herbal drink that contains betacyanin and flavonoid compounds act antioxidants. This study aims to determine the equivalence vitamin C levels in steeping Flower L) using DPPH method. The method simple, fast, inexpensive can be measure ability an antioxidant. Data analysis absorbance was calculated TAC (Total Antioxidant ...

INTRODUCTION We investigated the role of ATP-sensitive potassium channels and L-type calcium channels in morphine-induced hyperalgesia after nociceptive sensitization. METHODS We used a hotplate apparatus to assess pain behavior in male NMRI mice. Nociceptive sensitization was induced by three days injection of morphine and five days of drug free. On day 9 of the schedule, pain behavior test ...

This experiment was performed to investigate the effect of Azolla and rice straw mixed compost in peat substitution on Dieffenbachia amoena. Factorial experiment based on a completely randomized design with two factors of nutrient solution in 2 levels (1- without solution, 2- with 130 mg N/ l, 32 mg P /l and 117 mg K/ l) and 5 levels of Azolla and rice straw mixed compost (zero, 15, 30, 45 and ...