A series of twenty six arylpiperazine and aminoalkanol derivatives of 4-azatricyclo[5.2.2.0(2,6)]undecane-3,5,8-trione have been prepared. The synthesized compounds were evaluated for their cytotoxicity and anti-HIV-1 activity in MT-4 cells.

background: mutations of gjb2 gene encoding connexion 26 are the most common cause of hearing loss in many popula­tions. a very wide spectrum of gjb2 gene mutations associated with hearing loss have been detected but pathogenic role has been tested only for a part of them. in this study, we have provided genetic evidence on the pathogenicity of our previ­ously reported novel gjb2 allelic varian...

As we saw at the beginning of this course, the exponential growth of errors iterating a chaotic dynamical system implies that a computer generated trajectory from some initial condition will rapidly diverge from the true orbit due to truncation errors or approximations in the numerical integration scheme, so that after a relatively short time the computer generated orbit will have no correlatio...

Landscape fragmentation can be a major threat to the persistence of species with very specific habitat and area requirements (e.g., Wilcove et al., 1986). Such a species is the northern spotted owl (Strix occidentalis caurina), whose populations are experiencing fragmentation at a number of spatial scales. The analyses we discuss here focus on the geographic scale (Lord and Norton. 1990) and ar...

Introduction: Diarrhea remains a major cause of death in children under 5 years are considered. However, following the overuse of antibiotics and the arbitrary use of broad-spectrum antibiotic, as well as diarrhea associated with antibiotic use is increasing. This study aimed to determine the role of probiotics in the prevention and treatments of diarrhea in children have been conducted.   Mate...

Joint Implementation Supervisory Committee Tenth meeting Report Annex 3 Annex 3 SCHEDULE OF MEETINGS OF THE JOINT IMPLEMENTATION SUPERVISORY COMMITTEE IN 2008 Mo Tue Wed Thur Fri Sat Sun Mo Tue Wed Thur Fri Sat Sun Mo Tue Wed Thur Fri Sat Sun Mo Tue Wed Thur Fri Sat Sun Mo Tue 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17...

Results Rash (14/26), arthritis (14/26), and deafness (12/26) were the most common features. Episodic fever accounted in 8/26 patients. 14/26 patients did not present episodic course and disease onset was over 10 years in 17/26 patients. 2/26 patients developed amyloidotic hemorrhagic cystitis and other 2/26 patients explained olfactive disfunction. Amyloidosis was confirmed in 2/26 patients an...