Intramuscular (IM) epinephrine via autoinjector has suboptimal compliance/use; alternatives are needed. We compared bioavailability and cardiovascular effects of intranasal (IN) nasal spray versus IM epinephrine. This open-label, randomized, 5-treatment, 5-way crossover study included 25 healthy participants aged 19–45 years. Epinephrine administrations were: 6.6-mg IN (1x6.6-mg), 4.4-mg (2x2.2...

We investigated the effects of fructooligosaccharides (FO)-feeding on the absorption of iron (Fe), calcium (Ca) and magnesium (Mg) and on the biochemical parameters in Fe-deficient anemic rats. Fe-deficient anemic rats were made by feeding an Fe-deficient diet for 3 weeks. Then these Fe-deficient rats were fed an experimental diet that contained one of two levels of Fe (15 or 30 mg/kg diet), in...

production of thermostable alkaline protease in tray bioreactor for solid state fermentation is a unique process which may lead to an economical approach for production of enzyme from agricultural waste or low cost substrate. in solid state fermentation using tray bioreactor, several agricultural residues such as rice bran, sugarcane bagasse, wheat bran, barely bran, corn meal and corn husk wer...

BACKGROUND AND OBJECTIVES Tricyclic antidepressants (TCAs) are widely used as analgesics in chronic lumbar pain and neuropathic pain. The objective of this study was to evaluate the electrocardiographic changes in patients with chronic pain treated with amitriptyline or imipramine. METHODS Forty patients, ages 26 to 81 years (57.27 +/- 13.65 years) of both genders (female 19, male 21), with n...

this work examined the simultaneous saccharification and fermentation (ssf) process for the biological conversion rice wastewater into ethanol using co-culture of aspergillus niger (a. niger) and saccharomyces cerevisiae (s. cerevisiae) in batch condition. in this study, the a. niger and s. cerevisiae were used for hydrolysis and production of ethanol from rice wastewater, respectively. the effe...

BACKGROUND Vesnarinone, an inotropic drug, was shown in a short-term placebo-controlled trial to improve survival markedly in patients with severe heart failure when given at a dose of 60 mg per day, but there was a trend toward an adverse effect on survival when the dose was 120 mg per day. In a longer-term study, we evaluated the effects of daily doses of 60 mg or 30 mg of vesnarinone, as com...

OBJECTIVES The purpose of this study was to assess the in vitro P2Y12 receptor inhibitory effects of cangrelor on platelets from patients on maintenance prasugrel therapy treated with 2 reloading dose regimens. BACKGROUND Despite its more potent and rapid antiplatelet effects compared with clopidogrel, recent studies have shown variability in prasugrel-mediated P2Y12 receptor inhibition, part...

In the European Union, the use of the insecticide NeemAzal T/S (standardised variant 1% of the active ingredient azadirachtin) is authorised in organic agriculture. The objective of this study was to determine the toxic effects of NeemAzal T/S at concentrations of 3, 10, 30, and 60 mg/l on the morphometric and condition characteristics, mortality, hatching, and histopathology of early-life stag...

 Background: Ferula persica has been used in traditional medicine for treatment of high blood pressure. In this study acute and chronic effect of aqueous F. persica extract on BP of hypertensive rats and its possible mechanism of action have been investigated. Methods: Eighty two male Wistar rats were divided into 12 experimental groups. Hypertension was induced by Goldblatt method in ...