objective(s): to explore the correlation between expression patterns and functions of mir-383 and ldha in hepatocellular cancer (hcc). materials and methods: we detected the expression of mir-383 and ldha in 30 hcc tissues and their matched adjacent normal tissues using qrt-pcr. then we performed mtt assay, foci formation assay, transwell migration assay, glucose uptake assay and lactate produc...

there exists compelling evidence that toll-like receptor 3 (tlr3) agonists can directly affect human cancer cells. the aim of this study was to investigate anti-cancer effects of tlr3 agonist in human breast cell line. we assessed potential effects of poly (a:u) on human breast cell line (mda-mb-231)  on a dose-response and time-course  basis. human breast cell line  mda-mb-231  was treated wit...

objective(s): as t-cell immunoglobulin and mucin domain 3 (tim-3) is an immune regulatory molecule; its blocking or stimulating could alter the pattern of immune response towards a desired condition. based on the unique features of nanobodies, we aimed to construct an anti-tim-3 nanobody as an appropriate tool for manipulating immune responses for future therapeutic purposes. materials and meth...

introduction: neurodegenerative diseases are progressive disorders that could impair neuronal functions and structures. oxidative stress and mitochondrial dysfunction are involved in the etiology of neurodegenerative diseases such as alzheimer’s disease, parkinson’s disease and etc. gemfibrozil is used as a therapeutic drug for hyperlipidemia. it has been shown that gemfibrozil is neuroprotecti...

Displacement reaction of 2,3-dichloroquinoxaline with secondary amines in boiling ethanol afforded it`s mono aminoquinoxaline derivatives. Further reaction of the latter compounds with sodium azide in warm dimethylsulfoxide achieved a group of 4-amino tetrazolo[1,5-a]quinoxaline derivatives. 1HNMR spectra of these compounds are discussed.