We have characterized the pharmacological antagonism, i.e., neutral antagonism or inverse agonism, displayed by a number of a-blockers at two a1-adrenergic receptor (AR) subtypes, a1aand a1b-AR. Constitutively activating mutations were introduced into the a1a-AR at the position homologous to A293 of the a1b-AR where activating mutations were previously described. Twenty-four a-blockers differin...

Maryam Sadat Ghasemzadeh was born in Ghaen/ Southern Khorasan, Iran. She received her B.Sc. in Pure Chemistry from Imam Khomeini International University and M.Sc. in Organic Chemistry from Birjand University under the supervision of Professor Sara Sobhani. She is currently studying her Ph.D. in Ferdowsi University of Mashhad under the supervision of Professor Batool Akhlaghinia. Her current re...

In the future, the Baltic Sea ecosystem will be impacted both by climate change and by riverine and atmospheric nutrient inputs. Multi-model ensemble simulations comprising one IPCC scenario (A1B), two global climate models, two regional climate models, and three Baltic Sea ecosystem models were performed to elucidate the combined effect of climate change and changes in nutrient inputs. This st...

Winter storm-track activity over the Northern Hemisphere and its changes in a greenhouse gas scenario (the Special Report on Emission Scenarios A1B forcing) are computed from an ensemble of 23 single runs from 16 coupled global climate models (CGCMs). All models reproduce the general structures of the observed climatological storm-track pattern under present-day forcing conditions. Ensemble mea...

This study is intended to examine the past drought and predict future drought scenarios for Arkansas-Red River Basin with comprehensive drought indices ranging from meteorology, hydrometeorology to hydrology. In this proceeding, we present some early results and analysis with the Standardized Precipitation Index (SPI) and the Palmer Drought Severity Index (PDSI). Historical climate data within ...

global warming caused by human activity and climate change is one of the issues attracted that has attention of many climate scientists. the relationship between climate parameters should be used in climate change studies to understand the complex nature of the environment and predict changes in the future. the reliable tool to investigate climate change effects on different systems is using th...

1. introduction climatic change is one of the most important challenges human beings have confronted with in recent centuries due to its severe effects on water resources, agriculture, energy, tourism and even human bioclimatic. developing strategies, making decisions with awareness about water consumption in different parts in the future, and available water resources management require climat...

[1] Stratospheric ozone is expected to increase during the 21st century as the abundance of halogenated ozone‐depleting substances decrease to 1960 values. However, climate change will likely alter this “recovery” of stratospheric ozone by changing stratospheric temperatures, circulation, and abundance of reactive chemical species. Here we quantify the contribution of different mechanisms to ch...