In this study the role of adenosine A1 and A2A receptors of the hippocampal CA1 region on piriform cortex-kindled seizures was investigated in rats. Animals were kindled by daily electrical stimulation of piriform cortex. In fully kindled rats, N6-cyclohexyladenosine (CHA; a selective A1 receptor agonist), 1,3-dimethyl-8-cyclopenthylxanthine (CPT; a selective A1 receptor antagonist), CGS21680 h...

Adenosine acts as a neuromodulator through A1 and A2 receptors. The adenosine analogs have been recognized, among other effects, as strong depressors of the locomotor activity by acting on striatal A2 receptors. Moreover, the A2a receptor subtype is exclusively expressed in the striatum. To elucidate at the cellular level the roles of adenosine in the basal ganglia, the anatomical and functiona...

In the absence of efficient disease-modifying treatments for Parkinson’s disease (PD), research has focused on identifying potential environmental factors whose modulation may prevent or slow progression this neurodegenerative disorder. Compelling epidemiological evidence suggests that caffeine consumption is inversely associated with risk developing PD. Further experimental findings demonstrat...

The aim of the study was to investigate the effects of stable adenosine receptor agonists on bone marrow hematopoiesis by utilizing the model of hematopoietic damage induced by 5-fluorouracil (5-FU), a cycle-specific cytotoxic agent. Effects of a non-selective agonist NECA activating all the known adenosine receptors (A1, A2A, A2B, A3) and of the selective agonists for A1 (CPA), A2A (CGS 21680)...

The uroepithelium of the bladder forms an impermeable barrier that is maintained in part by regulated membrane turnover in the outermost umbrella cell layer. Other than bladder filling, few physiological regulators of this process are known. Western blot analysis established that all four adenosine receptors (A1, A2a, A2b, and A3) are expressed in the uroepithelium. A1 receptors were prominentl...

MECHANISMS MEDIATING MODULATION OF CARDIOPULMONARYCHEMOREFLEX CONTROL OF REGIONAL SYMPATHETIC ACTIVITY BYADENOSINE A1 and A2a RECEPTORS LOCATED IN THE NTSbyZELJKA MINICAugust 2013Advisor: Dr. Tadeusz J. ScisloMajor: PhysiologyDegree: Doctor of PhilosophyAdenosine is an important neuromodulator of cardiovascular control at the levelof the nucleus of th...

A sodium salt of 2-(fur-2-yl)-6-nitro-1,2,4-triazolo[1,5-a]pyrimidin-7-one as a close structural analogue ZM-241385 was obtained. This heterocycle can serve an effector for A2a adenosine receptors and possesses antiseptic activity. The structures compounds were confirmed based on the data 1H, 13C NMR spectroscopy, IR elemental analysis. structure 2-furyl-6-nitro-1,2,4-triazolo[1,5-a]pyrimidin-7...

Oligodendrocyte-formed myelin sheaths allow fast synaptic transmission in the brain and their degeneration leads to demyelinating diseases such as multiple sclerosis. Remyelination requires differentiation of oligodendrocyte progenitor cells into mature oligodendrocytes but, chronic neurodegenerative disorders, remyelination fails due adverse environment. Therefore, a strategy prompt cell towar...

PDRN is a proprietary and registered drug that possesses several activities: tissue repairing, anti-ischemic, and anti-inflammatory. These therapeutic properties suggest its use in regenerative medicine and in diabetic foot ulcers. PDRN holds a mixture of deoxyribonucleotides with molecular weights ranging between 50 and 1,500 KDa, it is derived from a controlled purification and sterilization ...

lar AMPc in respiratory tissue were initially attributed to other mechanisms, it is currently accepted that the changes are due to the competitive antagonism of these bases with receptors of the neurotransmitter adenosine. Adenosine exerts a depressor effect with important repercussions in the functioning of the cardiovascular, renal, immune and central nervous systems. In recent years the sear...