Urea movement across plasma membranes is modulated by specialized transporter proteins that are products of two genes, termed UT-A and UT-B. These proteins play key roles in the urinary concentrating mechanism and fluid homeostasis. We have isolated and characterized a 1.4-kb cDNA from testes encoding a new isoform (UT-A5) belonging to the UT-A transporter family. For comparison, we also isolat...

AS-3-Ketosteroid isomerase of Pseudomonas testosteroni is a homogeneous and crystalline enzyme that promotes the irreversible conversion of A5-3-ketosteroids to A4-3-ketosteroids (1, 2). This enzyme is one of the most active catalytic proteins known, since each mole (molecular weight 40,800) converts 16.7 x lo6 moles of A5-androstene-3, 17-dione (I) to A4-androstene-3, 17dione (II) per minute a...

The membrane immunoglobulin heavy chain (Am) plays a feedback role during the pre-B stage of B lymphocyte differentiation . In pre-B cell lines, Am associates with two surrogate light chain proteins. The w chain is disulfide linked to p, and was predicted to be the product of the X5 gene. The t chain is noncovalently associated with Am. We demonstrate that the w protein is indeed the product of...

OBJECTIVE Annexins are Ca(2+)-dependent phospholipid binding proteins. Externalized annexin A5 has been recently suggested to have a proapoptotic effect. Our aim was to determine whether annexin A5, which is intracellular in cardiomyocytes, could be translocated and/or externalized and play a role during the apoptotic process. METHODS Apoptosis was induced in rat cardiomyocytes by continuous ...

We introduce certain Backlund transformations for rational solutions of the Painleve VI equation. These act on a family tau functions. They are obtained from reducing Hirota bilinear equations that describe relation between points in 3 component polynomial KP Grassmannian. In this way we obtain root lattice A5. also show A5 can be related to F4(1) lattice. thus relate functions, parametrized by...

Antiphospholipid antibodies represent a heterogeneous group of autoantibodies directed against anionic phospholipids (PLs) usually linked to protein cofactors. Their presence during the antiphospholipid syndrome is associated with risks of thrombosis and fetal losses. Among 5 randomly selected monoclonal antiphospholipid antibodies, all originating from a single patient suffering from this auto...

Antiphospholipid antibodies represent a heterogeneous group of autoantibodies directed against anionic phospholipids (PLs) usually linked to protein cofactors. Their presence during the antiphospholipid syndrome is associated with risks of thrombosis and fetal losses. Among 5 randomly selected monoclonal antiphospholipid antibodies, all originating from a single patient suffering from this auto...