Reduction of aldehydes and ketones to the corresponding alcohols in the presence of sodium cyanoborohdride as reductive agent and Tonsil clay as catalyst under solvent free conditions was investigated. Tonsil (catalyst) decreased the reduction time of each aldehyde and ketone to proportional alcohols in comparison with their reduction in the absence of catalyst with high degree purity of alcoho...

An efficient method is described for the mild and rapid tetrahydropyranylation of alcohols and phenols using a catalytic amount of N-chlorosaccharin (1 mol %) and 3, 4-dihydro-2H-pyran under solvent-free condition at room temperature. Benzylic alcohols and phenols containing electron withdrawing or donating groups in various positions of phenyl ring, cinamyl alcohol, primary, ...

The hydration of propargylic alcohols is a green route to synthesize a-hydroxy ketones. Herein a CO2reactive ionic liquid (IL), [Bu4P][Im], was found to display high performance for catalyzing the hydration of propargylic alcohols in the presence of atmospheric CO2, and a series of propargylic alcohols could be converted into the corresponding a-hydroxy ketones in good to excellent yields. In t...

We investigated the acute toxic and metabolic effects of 23-aliphatic alcohols (16 saturated and 7 unsaturated) in the isolated perfused rat liver at a concentration of 65.1 mmol/l (approximately 0.3% ethanol). The capacity of the straight chain primary alcohols (methanol, ethanol, 1-propanol, 1-butanol and 1-pentanol) to release the enzymes glutamate-pyruvate transaminase (GPT), lactate dehydr...

A persistent challenge in membrane biophysics has been to quantitatively predict how membrane physical properties change upon addition of new amphiphiles (e.g., lipids, alcohols, peptides, or proteins) in order to assess whether the changes are large enough to plausibly result in biological ramifications. Because of their roles as general anesthetics, n-alcohols are perhaps the best-studied amp...

Crude cell-free preparations of Botrytis cinerea were found to oxidize straight-chain primary alcohols (except methanol), aromatic primary alcohols, and unsaturated primary alcohols. The resulting products were the corresponding aldehydes and an equal molar quantity of hydrogen peroxide.

Hydrogen sulphide (H2S), a newly identified gasotransmitter, can be endogenously produced by cystathionine gamma-lyase (CSE) in the cardiovascular system. This study investigated role of CSE/H2S system on lipid overload-induced lipotoxicity and cardiac senescence. Lipid overload rat cardiomyocyte cells (H9C2) promoted intracellular accumulation lipid, oxidative stress, mitochondrial dysfunction...

Aliphatic alcohols inhibited the activity of human matrix metalloproteinase 7 (matrilysin) competitively with K(i) of 6.1-19.4% (v/v) or 0.66-4.80 M. From the relationship between the structures of alcohols and their K(i) values, alcohols are considered to bind the hydrophobic S1' subsite most plausibly, and the size of the pocket was estimated to be large enough to accommodate the length of 1-...

Trimethylsilylation of alcohols and phenols were carried out under solvent-free conditions with hexamethyldisilazane (HMDS) using LaCoO3 perovskite. LaCoO3 as an efficient catalyst accelerated this reaction under milder condition. The advantages of this method are evident regarding, easy separation, low cost and low catalyst loading, lack of pollution, easy work-up, and selective protection of ...