OBJECTIVE To determine whether low concentrations of a dopamine agonist worsen parkinsonism, which would suggest that activation of presynaptic dopamine autoreceptors causes a super-off state. DESIGN Randomized, double-blind, placebo-controlled, crossover clinical trial. SETTING Academic movement disorders center. PATIENTS Patients with Parkinson disease and motor fluctuations. INTERVEN...

The 2014 Lasker-DeBakey Clinical Medical Research Award has been presented toMahlonDeLong,MD, and Alim-Louis Benabid,MD,PhD, to recognizeandhonor themfor theiroutstanding work in the development of high-frequency deep brain stimulation of the subthalamic nucleus for the treatment of patients with advanced Parkinson disease. This Viewpoint provides a summaryof their discoveries in understanding ...

PURPOSE To determine whether the proton spectra from patients with clinically diagnosed Parkinson disease differ from the spectra of age-matched healthy subjects with respect to the major cerebral metabolite resonances as well as lactate. METHODS Fourteen patients with Parkinson disease (38 to 81 years of age) and 13 healthy control subjects (37 to 81 years of age) were studied using image-gu...

conclusions since the severity of the behavioral symptoms in the 6-ohda-induced model of parkinson disease reflects the degree of the lesion in substantia nigra (sn) dopaminergic neurons, it is suggested that using the combination had neuroprotective effects. the obtained data suggest a synergistic neuroprotective and antiparkinsonian effect for flu, glib and b com. at least, a part of this eff...

BACKGROUND AND PURPOSE The pathology of Parkinson disease leads to morphological brain volume changes. So far, the progressive gray matter volume change across time specific to patients with Parkinson disease compared controls remains unclear. Our aim was to investigate the pattern of gray matter changes in patients with Parkinson disease and to explore the progressive gray matter volume change...

Parkinson disease is one of the common brain diseases caused by dopaminergic neuronal loss in the substantia nigra and dopaminergic fiber loss in the striatum. In the present study, the effects of treadmill exercise on motor performance, dopaminergic loss of neurons and fibers, and α-synuclein expression in the nigrostriatum were evaluated using rotenone-induced Parkinson rats. For the inductio...