Traditional medicine has been developed rapidly throughout the world to treat hyperlipidemia. However, use of a single compound in hyperlipidemia treatment usually have low efficacy. Therefore, combination ingredients is bound more synergistic impact therapy. This research aimed examine hypolipidemic potential mountain papaya (MPE) and bitter melon fruit ethanolic extract (BME) alloxan-induced ...

Many plants are claimed to possess antidiabetic and antioxidant activity. In practice, it is being increasingly recognized to be an alternative approach to modern medicine. This study assess the antioxidant capacity of Tinospora cordifolia stem methanol extract in daily oral administration of 500 mg/kg of body weight for 40 days in alloxan induced diabetic rats. The erythrocytes membrane lipid ...

Nonglucose reducing substances in blood Constitute the “saccharoid fraction,” which increases both in hyperand hypoglycemia. The phosphate esters, including weak-acid phosphates and fructose-i ,6-diphosphate, constitute 14 to 25% of the saccharoid fraction in whole blood, 2 to 9% in plasma, and 24 to 35% in erythrocytes of normal rats treated with insulin or epinephrine and of alloxan diabetic ...

Background/Objectives: Diabetes mellitus impairs glucose homeostasis causing neurological disorders due to perturbation in utilization of glucose. The mechanisms responsible for failure of glycaemic control in diabetes need to be thoroughly elucidated and hence the present study was initiated. Material and Methods: Diabetes was induced in albino rat models with alloxan monohydrate (40 mg/Kg int...

The objective of this study was to evaluate the antidiabetic activities of methanol and aqueous extracts of Pergularia daemia in alloxan induced diabetic rats. Methods used was methanol and aqueous extracts (250 mg/kg b.w.) of P. daemia was administered to alloxan induced diabetic mice for 21 days and blood glucose levels of the diabetic rats were monitored at intervals of hours and days throug...

The electron microscopic alterations of the alveolar septum in advanced hemodynamic and alloxan-induced pulmonary edema were compared. Pulmonary edema was produced in anesthetized dogs by means of increased left atrial pressure and hemodilution and by alloxan administration. Sections of pulmonary tissue from these dogs and similarly anesthetized controls were processed for and examined by light...

We investigated the effects of Hericium erinaceus (HEE) on alloxan induced diabetic neuropathic pain in laboratory rats. Alloxan induced diabetic rats were administered orally HEE. After 6 weeks of treatments, treatment with HEE 40 mg/kg in diabetic animals showed significant increase in pain threshold and paw withdrawal threshold and significant decrease in serum glucose and urine glucose. We ...

To reinvestigate the relationship between diabetes and atherosclerosis in rabbits, we fed alloxan-diabetic, alloxan-nondiabetic, and control rabbits a low cholesterol atherogenic diet for up to 40 weeks. Concentrations of plasma total cholesterol, phospholipids, and triglycerides were higher, the percentage of very low density lipoproteins was higher, and the percentage of high density lipoprot...

Recently, it is implicated that the abnormality of Akt signaling pathway is involved in the diabetic pathology. Previous studies have demonstrated that berberine could decrease blood glucose by elevating liver glycogen synthesis. However, the underlying mechanism is still unclear. In the present study, we investigated the effects of berberine on fasting blood glucose, liver glycogen, Akt, Glyco...

The effect of Black plum, Syzygium cuminii (Linn.) Skeels (syn. S. jambolanum DC.) seed extract on lipid peroxidation in alloxan induced diabetic rats was studied. Alloxan 150mg (mg/kg body weight) increased significantly the glucose level in blood and induced the Lipid Peroxidation (LPO) in liver. The antioxidant enzymes Catalase (CAT), Reduced Glutathione (GSH), Glutathione peroxidase (GPx), ...