Since the discovery of alloxan diabetes in 1943 (l), several investigators have discussed the possibility that alloxan might be involved in some way in the pathogenesis of diabetes mellitus. Dunn et al. (1) considered this on the ground that alloxan was chemically related to uric acid. Lazarow (2) reviewed the possible relation of alloxan to diabetes and discussed the pro_ tective mechanism of ...

In the present study male albino rats weighing 200 ± 50 g were made diabetic by injection with a single ip dose of alloxan (100 mg/kg). Another group of rats was simultaneously treated with alloxan (100 mg/kg) and a single ip dose of zinc chloride (ZnCl2) (5 mg/kg). Blood and tissue samples were collected at 24, 48 and 72 hours posttreatment in both groups. Plasma insulin was significantly high...

This study investigated the behavioral and biochemical parameters of DM1 as a risk factor in an animal model of schizophrenia (SZ). All groups: 1 Control (saline+saline); 2 Alloxan (alloxan+saline); 3 Ketamine (saline+ketamine); 4 (Alloxan+Ketamine) were fasted for a period of 18h before the subsequent induction of DM via a single intraperitoneal (i.p) injection of alloxan (150mg/kg). From the ...

It was the purpose of this investigation to study the reaction between alloxan and the sulfhydryl group of cysteine and compounds containing cysteine. Alloxan injected into animals produced diabetes (1). Cysteine or glutathione injected prior to alloxan, but not after alloxan, protected animals from diabetes (2). On the basis of these data it was postulated that alloxan produced diabetes by the...

The diabetogenic action of alloxan is thought to be initiated by generation of reactive oxygen species (ROS). Ascorbate can be an antioxidant in a predominantly aqueous environment, such as plasma and extracellular fluids. We have investigated the generation of ROS in the interaction of alloxan with ascorbate. Rapid oxygen consumption was observed in the reactin system of alloxan with ascorbate...

The cytotoxic alloxan is the most prominent diabetogenic chemical agent in experimental diabetes research. Alloxan has been found to be selectively toxic to liver hepatocytes. The experiments aim to understand the effect of alloxan on cytomorphology of liver in rat. Treatment with alloxan caused central vein congestion with significant dilatation of sinusoidal spaces. The liver of the alloxan t...

The efficacy of alcoholic extract Cladophora glomerate(Cg) algae in lowering levels glucose , cholesteroland triglycerides male rats with diabetes induced Alloxan and as will the histopathology thepancreas was investigated this report. results showed that reduced ofglucose cholesterol significantly a histological examination pancreatic tissuerevealed therapeutic potential glomerate inhibiting a...

A number of compounds have been found to prevent the diabetic action of alloxan when administered immediately before the al1oxan.l The writers have observed that the oxidation-reduction dye, methylene blue, not only is protective against the diabetogenic action of alloxan when given before the alloxan, but also exerts a marked blood sugarlowering effect when administered to rats previously made...

BACKGROUND This study aimed to examine the effects of intermittent and continuous swimming training on muscle protein metabolism in neonatal alloxan-administered rats. METHODS Wistar rats were used and divided into six groups: sedentary alloxan (SA), sedentary control (SC), continuous trained alloxan (CA), intermittent trained alloxan (IA), continuous trained control (CC) and intermittent tra...

SYNOPSIS This report was designed to grasp exactly the action of alloxan by the true tolerance test reported by Takeuchi (1961). The action of alloxan is manifested in two different ways depending on the dose; e-k decreased in a smaller dose and increased in a larger dose. The former is named mesoxalic acid-like action and the latter alloxan-like action. The effect of the compounds related with...