introduction : intestinal ischemia and reperfusion (i-i/r) is an insult associated with acute respiratory distress syndrome (ards). herein we evaluate the dose-response effect of low-level laser therapy (lllt) on lung inflammation induced by i-i/r. methods : mice were subjected to mesenteric artery occlusion (45 min) and killed after clamp release and intestinal reperfusion (2h). increasing dos...

Many molecular and cellular abnormalities detected in the diabetic retina support a role for IL-1β-driven neuroinflammation in the pathogenesis of diabetic retinopathy. IL-1β is well known for its role in the induction and, through autostimulation, amplification of neuroinflammation. Upregulation of IL-1β has been consistently detected in the diabetic retina; however, the mechanisms and cellula...

Abstract Background Inflammasomes are intracellular multiprotein complexes that sense danger signals from damaged cells and pathogens assemble to mediate caspase-1 activation, which results in the proteolytic cleavage of pro-IL-1β IL-18 into bioactive forms. The NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome is a critical component innate immune system mediates activati...

Background: Hemin is an important sterile component that induces a neuroinflammatory response after intracerebral hemorrhage, in which NLRP3 inflammasome activation has also proved to be involved. Although microglial activation acts as a key contributor in the neuroinflammatory response, the relationship between hemin and NLRP3 in microglia remains poorly understood. Objective: To investigate w...

Abstract Objective In this study, we investigated the levels of interleukin‐1β (IL‐1β), IL‐18, and NOD‐like receptor pyrin domain‐containing 3 (NLRP3) inflammasome in patients with premature rupture membranes (PROMs). Methods We selected 60 pregnant women at Fourth Hospital Baotou between January 2019 July 2021. These were divided into three distinct groups: preterm PROM group 20 cases, term (T...

A study was conducted to the level of anti-inflammatory (IL-4) and pro-inflammatory (IL-1β, IL-6, IFNγ, TNFα) cytokines in 28 women with physiological pregnancy third trimester 23 incipient labor. It found that prenatal period, IL-1β IL-8 increases sharply, IL-4 decreases sharply. The levels IL-6 TNFα are also slightly elevated. Therefore, pro- parturient a physiologically proceeding is great i...