Myocardial infarction is the leading cause of death in world’s population. The sudden and progressive loss cardiomyocyte contractile cells due to disproportionate number new formation. This pathological condition will ultimately reduce function heart muscles. Platelet-rich plasma (PRP) last decade has been attracting attention regarding its role cell regeneration. content cytokines growth facto...

Abstract Background The repair of large bone defects is a great challenge for orthopedics. Although the development three-dimensional (3D) printed titanium alloy (Ti6Al4V) implants with optimized pore structure have effectively promoted osseointegration. However, due to biological inertia Ti6Al4Vsurface and neglect angiogenesis, some patients still suffer from postoperative complications such a...

Angiogenesis is an essential process in tumor growth. The concept of angiogenesis, when proposed by Folksman in 1971, had a great impact on cancer research and therapy, as the survival and proliferation of cancer depend on angiogenesis, which could be a target of cancer therapy. In subsequent decades, numerous antiangiogenic agents were developed, and some of them have been applied clinically. ...

Background and objectives: Datura innoxiaMilleris one of the two species of Datura (Solanaceae) which grow in Iran. There are many reports of the biological activities of Datura and in the present study the ability of Datura innoxia for inhibiting angiogenesis was evaluated. Methods: The methanol extract and petroleum ether, ...

Background: Angiogenesis, the development of new blood vessels, is an important process in tissue development and wound healing, but becomes pathologic when associated with solid tumor growth, proliferative retinopathies, and rheumatoid arthritis. Accurate and reliable qualification of neovascular (angiogenic) response, both in vitro and in vivo, is an essential requirement for the study of new...

The balance between embolic risk and bleeding represents a clinical challenge in cancer patient treatment, encouraging studies on adjuvant oncologic treatments. Thereby, this study evaluated the vitro effect of green tea extract (GTE) epigallocatechin-3-gallate (EGCG) hemostasis modulation antineoplastic melanoma cells (B16-F10) by applying platelet aggregation, angiogenesis viability cell assa...