In this era of precision oncology, there has been an exponential growth in the armamentarium of genomically targeted therapies and immunotherapies. Evaluating early responses to precision therapy is essential for "go" versus "no go" decisions for these molecularly targeted drugs and agents that arm the immune system. Many different response assessment criteria exist for use in solid tumors and ...

OBJECTIVE To prospectively validate the Montreal Cognitive Assessment (MoCA) in a UK memory clinic. METHOD We administered the MoCA and Mini-Mental State Examination (MMSE) to 32 subjects fulfilling diagnostic criteria for dementia, to 23 subjects fulfilling diagnostic criteria for mild cognitive impairment (MCI), and to 12 memory clinic comparison subjects, at baseline and then at 6-month fo...

Security remains to be a critical issue in the safe operation of Information Systems (IS). Identifying the threats to IS may lead to an effective method for measuring security as the initial stage for risk management. Despite many attempts to classify threats to IS, new threats to Health Information Systems (HIS) remains a continual concern for system developers. The main aim of this paper is t...

WHY: Depression is common in late life, effecting nearly five million of the 31 million Americans aged 65 and older. Both major and minor depression are reported in 13% of community dwelling older adults, 24% of older medical outpatients and 43% of both acute care and nursing home dwelling older adults. Contrary to popular belief, depression is not a natural part of aging. Depression is often r...

OBJECTIVE Personality disorder researchers are currently evaluating a range of potential solutions to problems with the DSM-IV diagnostic categories. This article proposes changes to the diagnostic categories and criteria based on empirical findings from a national sample of patients with personality disorder diagnoses. METHOD The Shedler-Westen Assessment Procedure (SWAP-200) is a personalit...