In the present study, we investigated intervention effects of a purified Polygonatum cyrtonema polysaccharide (PCP) on high-fat diet (HFD)-induced atherosclerosis in male and female LDLr−/− mice. Results showed that HFD caused severe dyslipidemia, atherosclerotic lesions, oxidative damages inflammation mice, these seemed to be more pronounced males than females. However, above...

Highlights Developing international registry that would unify different patient populations not represented in other registries and studies, include patients with both manifested subclinical atherosclerosis, is crucial for cardiovascular field. The collected data can be used national guidelines, teaching learning guides, clinical practice. Abstract Multifocal atherosclerosis (MFA) one of the ke...

The emergence of new COVID-19 infection aggravated the existing issues and gave rise to challenges associated with impact viruses on atherosclerotic process development cardiovascular complications. Atherosclerosis is a multifactorial disease its progression largely determined by dyslipidemia chronic low-grade systemic vascular inflammation. There are number known be involved in maintaining inf...

Background and Aims: Macrophages contribute to the induction resolution of inflammation play a central role in chronic low-grade cardiovascular diseases caused by atherosclerosis. Human milk oligosaccharides (HMOs) are complex unconjugated glycans unique human that benefit infant health act as innate immune modulators. In this study, we tested hypothesis specific HMO attenuates atherosclerosis ...

Human blood groups ABO (BG) represent an important system in transfusion medicine and transplantation, have a role the development of heart disease. The current study was conducted with aim comparing types knowing most affected by atherosclerosis type 2 diabetes. Our consisted total (n192) population age range (45-70) years old overweight terms their BMI. first group included (n64) under Prec...

atherosclerosis is a chronic inflammatory disease of the arterial wall characterized by innate and adaptive immune responses to a variety of microbial and self-antigens. given the crucial role of adaptive immunity in the pathogenesis of atherosclerosis, this study was performed to investigate the proliferative response of peripheral blood mononuclear cells (pbmc) and interleukin (il)-2 producti...

Background and Aims : Mimics of mast cell-derived heparin proteoglycans (HEP-PG) can be tailored to molecules carrying both antiplatelet anticoagulant properties. These dual (APAC) constructs also shield adhesion such as P-selectin VCAM-1 expressed by endothelial cells upon atherosclerosis development. We hypothesize that via this way, APAC prevents macrophage accumulation lesion In study, we t...