The healing of bone defects is a challenge for both tissue engineering and modern orthopaedics. This problem has been addressed through the study of scaffold constructs combined with mechanoregulatory theories, disregarding the influence of chemical factors and their respective delivery devices. Of the chemical factors involved in the bone healing process, bone morphogenetic protein-2 (BMP-2) h...

We investigated the interaction between angiogenic and osteogenic factors in bone formation and bone healing with ex vivo gene therapy using muscle-derived stem cells genetically engineered to express human bone morphogenetic protein-4 (BMP4), VEGF, or VEGF-specific antagonist (soluble Flt1). Our results show that although VEGF alone did not improve bone regeneration, it acted synergistically w...

OBJECTIVES Compare histologic and biomechanical differences of tendon-to-bone healing between autologous and allogeneic bone transplants. MATERIALS AND METHODS Adult, healthy, New Zealand white rabbits were used to establish the extra-articular tendon-to-bone healing model with the left hind limb transplanted with allogeneic bone and the right hind limb transplanted with autologous bone. Afte...

The effects of using a newly available water-soluble polymer bone hemostatic material in a contaminated environment were assessed in a rabbit tibial defect model. Infection rates and healing of polymer-treated bone were compared with the infection and healing of bone wax-treated bone and untreated controls after a bacterial challenge. Defects created in 24 rabbit tibias were treated with the po...

BACKGROUND Despite being an effective analgesic for children with fractures, some clinicians may avoid prescribing ibuprofen due to its potentially harmful effect on bone healing. OBJECTIVE To determine if exposure to ibuprofen is associated with an increased risk of bone healing complications in children with fractures. METHODS We performed a retrospective study of children aged 6 months t...

Bombyx mori cypovirus is a major pathogen which causes significant losses in silkworm cocoon harvests because the virus particles are embedded in micrometer-sized protein crystals called polyhedra and can remain infectious in harsh environmental conditions for years. But the remarkable stability of polyhedra can be applied on slow-release carriers of cytokines for tissue engineering. Here we sh...

Suspensory ligament injuries are challenging because healing is slow and reinjuries are common. Healing requires growth factors that stimulate angiogenesis, mitogenesis, and matrix formation. Bone marrow contains growth factors, cells, and fibrinogen, which facilitate healing of damaged tissues. In 100 horses with ligament damage, bone marrow seems to enhance healing. Author’s address: Alamo Pi...

introduction: the low regeneration of bone in defective bones causes therapeutic problems. various strategies to assess the healing of bone defects have been used which they include histological and histo-chemical analysis in an invasive study. the purpose of this study was to determine the ultrasonic parameters of bone as a promising noninvasive technology for assessing bone repair process. ma...

OBJECTIVES The monitoring of fracture healing is a complex process. Typically, successive radiographs are performed and an emerging calcification of the fracture area is evaluated. The aim of this study was to investigate whether different bone healing patterns can be distinguished using a telemetric instrumented femoral internal plate fixator. MATERIALS AND METHODS An electronic telemetric s...