Epithelial cells and phagocytes contain antimicrobial polypeptides that participate in innate host defense. A recently cloned porcine beta-defensin, PBD-1, was detected by Northern organ blots exclusively in the tongue epithelium. We generated recombinant PBD-1 peptide by using a baculovirus-insect cell expression system and obtained two forms (PBD-142 and PBD-138), which differed by N-terminal...

Internet of Things (IoT) applications typically collect and analyse personal data that can be used to derive sensitive information about individuals. However, thus far, privacy concerns have not been explicitly considered in software engineering processes when designing IoT applications. In this paper, we explore how a Privacy-by-Design (PbD) framework, formulated as a set of guidelines, can he...

The performance of a processor is limited by the specific bottlenecks that a benchmark exposes while running on that processor. Since the quantification of these bottlenecks can be extremely time-consuming, our prior work proposed using the Plackett and Burman design as a statistically-rigorous, but timeefficient method of determining the processor’s most significant performance bottlenecks. In...

A three-step optimization strategy which includes one-factor-at-a-time classical method and different statistical approaches (Plackett-Burman design and response surface methodology) that were applied to optimize the antioxidant potential of Penicillium granulatum. Antioxidant activity was assayed by different procedures and compared with total phenolic content. Primarily, different carbon and ...

The polo-box domain (PBD) has critical roles in the mitotic functions of polo-like kinase 1 (PLK1). The replacement with partial ligand alternative through computational enrichment (REPLACE) strategy to develop inhibitors of protein–protein interactions has identified alternatives for the N-terminal tripeptide of a Cdc25C substrate. In addition, a peptide structure–activity relationship describ...

The spatial distribution of species, functional traits and phylogenetic relationships at both the regional and local scales provide complementary approaches to study patterns of biodiversity and help to untangle the mechanisms driving community assembly. Few studies have simultaneously considered the taxonomic (TBD), functional (FBD) and phylogenetic (PBD) facets of beta diversity. Here we anal...

Our goal is to make combinatorial problem-solving technology available to users who have no formal training in AI or OR. To achieve this aim, we have built a system, VICSS (Visual Constraint Specification System) that enables users to specify problems graphically. To simplify the specification process, VICSS relles heavily on progra~nming-by-demonstration (PBD) techniques. We believe, however, ...

Programming-by-demonstration (PBD) systems learn tasks by watching the user perform them. CIMA1 is an interactive learning system for modeling the data selected and modified by a user as he or she undertakes a task. Part of a PBD system, CIMA is invoked when user actions are matched to find a common description of their “operands.” Although the system’s interfaces to users and applications are ...